L-Carnitine Rompharm, 200 mg/ml 5 ml 5 pcs

Pharmacotherapeutic group:metabolic agent.

ATX code: A16AA01

Pharmacological action

Levocarnitine is a metabolic remedy; Has metabolic, anabolic, antihypoxic and antithyroid effect, activates fat metabolism, stimulates regeneration, increases appetite. Levocarnitine – a natural substance related to the B vitamins. It is a cofactor of metabolic processes to maintain the activity of coenzyme A (CoA).

Limits basic metabolism, slows down the breakdown of protein and carbohydrate molecules. It promotes penetration through mitochondrial membranes and the breakdown of long-chain fatty acids (palmitic acid and others) to form acetyl-CoA (necessary for pyruvate carboxylase activity during gluconeogenesis, ketone bodies formation, synthesis of choline and its esters, oxidative phosphorylation and formation of adenosine triphosphate (ATP). Mobilizes fat (presence of 3 labile methyl groups) from fat depots. It competitively displaces glucose and promotes fatty acid metabolic shunt, which activity is not limited by oxygen (unlike aerobic glycolysis). Therefore, the drug is effective under conditions of acute hypoxia (including brain) and other critical conditions.

It causes slight inhibition of the central nervous system (CNS), increases the secretion and enzymatic activity of digestive juices (gastric and intestinal), improves digestion.

Limits excess body weight and reduces fat in the skeletal muscles.

Enhances resistance to exercise, reduces lactate acidosis and regenerates ability to work after prolonged physical activity. At the same time it promotes economical use of glycogen and increases its reserves in the liver and muscles.

It has a neurotrophic effect, inhibits apoptosis, limits the affected area and restores the structure of nervous tissue.

Normalizes protein and fat metabolism, increased basic metabolism in thyrotoxicosis (being a partial antagonist of thyroxine); restores the alkaline reserve of the blood.

Pharmacokinetics

After intravenous administration, it disappears from the blood after 3 hours. Easily penetrates into the liver and myocardium, slower in muscles.

Extracted by the kidneys mainly as acyl esters (more than 80% in 24 hours).

Indications

L-Carnitine Rompharm is used as part of complex therapy for acute hypoxic conditions (acute cerebral hypoxia, ischemic stroke, transient ischemic attack). The drug is prescribed in acute, subacute and recovery periods of cerebral circulatory disorders. Used for dyscirculatory encephalopathy and various traumatic and toxic lesions of the brain, in the recovery period after surgery.

L-Carnitine Rompharm is indicated for primary and secondary carnitine deficiency, including in patients with chronic renal failure on hemodialysis; for cardiomyopathy, coronary heart disease (angina pectoris, acute myocardial infarction, post-infarction conditions), hypoperfusion due to cardiogenic shock and other disorders of myocardial metabolism.

Pharmacological effect

Pharmacotherapeutic group: metabolic agent.

ATX code: A16AA01

Pharmacological action

Levocarnitine is a means for correcting metabolic processes; has metabolic, anabolic, antihypoxic and antithyroid effects, activates fat metabolism, stimulates regeneration, and increases appetite. Levocarnitine is a natural substance related to B vitamins. It is a cofactor in metabolic processes that maintain the activity of coenzyme A (CoA).

Reduces basal metabolism, slows down the breakdown of protein and carbohydrate molecules. Promotes penetration through mitochondrial membranes and the breakdown of long-chain fatty acids (palmitic, etc.) with the formation of acetyl-CoA (necessary for ensuring the activity of pyruvate carboxylase in the process of gluconeogenesis, the formation of ketone bodies, the synthesis of choline and its esters, oxidative phosphorylation and the formation of adenosine triphosphate (ATP)). Mobilizes fat (presence of 3 labile methyl groups) from fat depots. Competitively displacing glucose, it turns on a fatty acid metabolic shunt, the activity of which is not limited by oxygen (unlike aerobic glycolysis), and therefore the drug is effective in conditions of acute hypoxia (including the brain) and other critical conditions.

Causes slight depression of the central nervous system (CNS), increases the secretion and enzymatic activity of digestive juices (gastric and intestinal), improves food absorption.

Reduces excess body weight and reduces fat content in skeletal muscles.

Increases the threshold of resistance to physical activity, reduces the degree of lactic acidosis and restores performance after prolonged physical activity. At the same time, it promotes economical consumption of glycogen and increases its reserves in the liver and muscles.

It has a neurotrophic effect, inhibits apoptosis, limits the affected area and restores the structure of nervous tissue.

Normalizes protein and fat metabolism, increased basal metabolism in thyrotoxicosis (being a partial antagonist of thyroxine); restores the alkaline reserve of the blood.

Pharmacokinetics

After intravenous administration, it disappears from the blood within 3 hours. It penetrates easily into the liver and myocardium, and more slowly into the muscles.

It is excreted by the kidneys mainly in the form of acyl esters (more than 80% in 24 hours).

Special instructions

L-Carnitine Rompharm is not addictive, because Levocarnitine is an endogenous substance.

An increase in glucose absorption when administering L-Carnitine Rompharm to patients with diabetes mellitus receiving insulin or oral hypoglycemic drugs can cause hypoglycemia. For this reason, in this category of patients, during treatment with L-Carnitine Rompharm, blood glucose levels should be constantly monitored for immediate correction of the dosage regimen of hypoglycemic drugs.

Long-term use of levocarnitine in high doses in patients with severe renal impairment may cause an increase in the concentration of potentially toxic metabolites, trimethylamine and trimethylamine-N-oxide, because these metabolites are usually excreted in the urine. In this case, urine, breath and sweat have an unpleasant odor.

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive vehicles and other potentially hazardous activities.

Active ingredient

Levocarnitine

Composition

1 ml of the drug contains:

active ingredient:

levocarnitine – 200.0 mg;

excipients: 1 M hydrochloric acid solution – up to pH 6.3 – 6.5, water for injection – up to 1.00 ml.

Pregnancy

L-Carnitine Rompharm should not be used during pregnancy and breastfeeding.

Contraindications

Hypersensitivity to levocarnitine or other components of the drug, pregnancy and breastfeeding.

The drug should be prescribed with caution for diabetes mellitus.

Side Effects

Mild symptoms of myasthenia gravis were observed only in uremic patients taking levocarnitine. Allergic reactions.

With rapid administration (80 drops/min or more), pain may occur along the vein, which disappears when the injection rate is reduced.

Interaction

Glucocorticoids promote the accumulation of levocarnitine in tissues (except the liver), other anabolic steroids enhance the effect.

Overdose

There are no data on toxicity in case of overdose of levocarnitine. Tolerance to the drug should be monitored during the first week of use and after each dose increase.

In case of overdose, treatment is prescribed to maintain vital functions, symptomatic treatment.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 ° C.
Out of the reach of children!

Shelf life

4 years.
Do not use after the expiration date!

Manufacturer

K.O.Rompharm Company S.R.L., Romania