Kornam, tablets 5 mg 20 pcs

Cornam is a blocker of peripheral postsynaptic a1-adrenoreceptors. It causes dilation of arterioles and venules, decreases OPPS and venous return to the heart, resulting in lowering of BP. After a single dose of the drug, the hypotensive effect lasts for 24 hours.

Blocking a1-adrenoreceptors of smooth muscles of prostate and bladder neck, the drug promotes normalization of urination in patients with benign prostatic hyperplasia.

The drug helps normalize lipid metabolism: it reduces cholesterol, triglycerides and low and very low density lipoproteins in the blood while increasing the amount of high density lipoproteins.

With systematic use of Kornam there is regression of left ventricular hypertrophy.

Indications

Active ingredient

Composition

1 tablet contains terazosin (in the form of dihydrate hydrochloride) 2 or 5 mg;

20 pieces in a pack.

How to take, the dosage

In benign prostatic hyperplasia, the initial dose is 1 mg once daily before bedtime. Gradually the dose is increased to 2-10 mg/day until the optimal effect is achieved. Therapeutic effect is usually observed 2 weeks after the start of treatment. To achieve a persistent effect the course of treatment should be 4-6 weeks.

In arterial hypertension, the drug is prescribed in an initial dose of 1 mg/day before bedtime. The dose is gradually increased until clinical effect is achieved. The maintenance dose is 1-10 mg once daily. The maximum daily dose is 20 mg. In case of temporary discontinuation of the drug, treatment is resumed according to the same scheme.

Interaction

In concomitant use of Kornam and beta-adrenoblockers, diuretics, calcium channel blockers, ACE inhibitors may increase the antihypertensive effect. Special caution is required when concomitant administration of terazosin and antihypertensive drugs of central action.

The absorption of terazosin is reduced with concomitant administration of adsorbents and antacids.

Adrenomimetics weaken the effect of terazosin.

In concomitant use of terazosin and NSAIDs, the antihypertensive effect may be reduced due to inhibition of prostaglandin synthesis and retention of fluid and sodium ions.

Special Instructions

To prevent the development of orthostatic arterial hypotension, treatment should begin with administration of Kornam at a dose of 1 mg/day before bedtime, after which the patient should be in bed for 6-8 hours.

The risk of orthostatic arterial hypotension (“first-dose effect”) is highest within 30-90 minutes after drug administration and increased in patients receiving beta-adrenoblockers and diuretics simultaneously, with decreased RBC, hyposolic diet, and when resuming treatment with the drug after a break (several days).

In case of temporary discontinuation of treatment, therapy is resumed with the same dose. In the course of treatment the level of specific prostate antigen does not change. Before initiating therapy of benign prostatic hyperplasia, prostate cancer must be excluded.

The patient must be informed about the increased risk of orthostatic hypotension with alcohol consumption, prolonged standing or exercise, and hot weather.

Within 12 hours after the first dose, after increasing the dose, or after discontinuing therapy, it is not recommended to engage in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Contraindications

With caution, the drug should be prescribed in angina, CHD, hepatic or renal failure, impaired cerebral circulation, type 1 diabetes.

Side effects

Cardiovascular system: rare – orthostatic hypotension.
CNS: drowsiness, dizziness, asthenia.
Others: nasal congestion.

Cardiovascular system side: orthostatic hypotension – “first-dose effect” (observed in 1% of patients, mostly receiving concomitant diuretics or beta-adrenoblockers), manifested by dizziness, tachycardia, fainting may occur; rarely – palpitations, peripheral edema, nasal congestion.
CNS: rarely – dizziness, asthenia, somnolence, visual perception failure.
Blood system: decrease (associated with hemodilution) of hematocrit, hemoglobin, leukopenia, hypoproteinemia, hypoalbuminemia.
Other: rare – decreased potency, nausea.

Overdose

Symptoms: pronounced decrease in BP, impaired coordination of movements, fainting.

Treatment: it is necessary to lay the patient with the head end of the bed down. If necessary, prescribe hypertensive agents, IV fluid administration. Hemodialysis is not effective.

Similarities