Klindovit, gel 1% 30 g

This antibiotic from the lincosamide group affects all strains of Propionibacterium acnes. Once applied to the surface of the skin, the product rapidly penetrates into the upper layers and accumulates in comedones, exhibiting significant antibacterial activity.

The average concentration of antibiotic in comedones exceeds the minimum level of suppression of Propionibacterium acnes strains, which are the causative agents of acne. From the time of application of the gel on the skin surfaces, rather low concentrations of clindamycin are determined in the composition of blood plasma and urine.

Indications

Acne.

Active ingredient

Composition

1 g of gel for external use contains:

Clindamycin (in the form of phosphate) 10 mg.

Auxiliary substances:

Methyl parahydroxybenzoate (nipagin),

allantoin,

tocopherol phosphate lauryliminodipropionate diarrhea,

propylene glycol,

Macrogol 400 (polyethylene oxide 400),

carbomer (copolymer, interpolymer),

sodium hydroxide,

purified water.

How to take, the dosage

The drug is used externally.

The gel is applied in a thin layer on the affected part of pre-cleaned and dried skin 2-3 times a day. Treatment should be continued for 6 to 8 weeks for a therapeutic effect; if necessary, it can be continued for up to 6 months.

Interaction

Clindamycin and erythromycin are antagonists, so the simultaneous administration of these antibiotics is not recommended. There is cross-resistance between clindamycin and lincomycin.

Clindamycin may increase the effects of muscle relaxants by disrupting neuromuscular transmission.

Special Instructions

Avoid contact with the eyes and mouth during use, and wash your hands after applying the gel.

Contraindications

Cautions:

– In patients under 12 years of age (no safety or efficacy data available).

– During lactation (breastfeeding).

– In patients predisposed to the development of allergic reactions.

– When taking muscle relaxants at the same time.

Side effects

The drug is usually well tolerated.

– Local reactions:Possible irritation (at the site of application), burning, itching, dry skin, erythema, flaking, increased sebum production, contact dermatitis.

– Systemic reactions: Pseudomembranous enterocolitis (possibility of development is present with systemic absorption of clindamycin).

Pregnancy use

Klindovit may be used topically during pregnancy if the estimated benefit of therapy for the mother exceeds the potential risk to the fetus.

If it is necessary to use during lactation, it is recommended to stop breastfeeding.

Similarities