Ketosteril, 50 mg 100 pcs.

Ketosteril is a combination drug.

It is a source of essential amino acids with minimal nitrogen administration. Ketone analogs of amino acids in the body are enzymatically transaminated into the corresponding L-amino acids, breaking down urea.

The drug promotes utilization of nitrogen-containing metabolic products and anabolism of proteins, while reducing serum urea concentrations. It improves nitrogen metabolism. Reduces the concentration of potassium, magnesium and phosphate ions in the blood.

In systematic use of the drug the improvement of patients with chronic renal insufficiency has been noted. In a number of cases it is possible to delay start of dialysis.

Indications

Protein-energy deficiency, prevention and treatment of disorders in adults and children over 3 years of age caused by altered protein metabolism in chronic renal failure and when protein is limited in the diet.

It is mainly used in patients with chronic renal failure with a glomerular filtration rate below 25 ml/min, which does not exclude use with a glomerular filtration rate above 25 ml/min.

Pharmacological effect

Ketosteril is a combination drug.

It is a source of essential amino acids with minimal nitrogen input. Ketone analogues of amino acids in the body are enzymatically transaminated into the corresponding L-amino acids, breaking down urea.

The drug promotes the utilization of nitrogen-containing metabolic products and protein anabolism while simultaneously reducing the concentration of urea in the serum. Improves nitrogen metabolism. Reduces the concentration of potassium, magnesium and phosphate ions in the blood.

With systematic use of the drug, an improvement in the condition of patients with chronic renal failure was noted. In some cases, it is possible to delay the start of dialysis.

Special instructions

Use for impaired renal function: Ketosteril is used during the entire period when the glomerular filtration rate is less than 25 ml/min.

In case of hypercalcemia, it is recommended to reduce the dose of vitamin D taken. If hypercalcemia persists, then the dose of Ketosteril, as well as other sources of calcium, should be reduced.

It is necessary to regularly monitor the calcium level and monitor the decrease in serum phosphate levels.

Ketosteril should be taken with meals to improve its absorption and conversion into the corresponding amino acids. It is necessary to ensure sufficient caloric content of food.

Active ingredient

Keto analogues of amino acids

Composition

Active substances:

DL-methyl-oxo-2-calcium valerinate (a-keto analogue of isoleucine) 67 mg,

Methyl-4-oxo-2-calcium valerinate (a-keto analogue of leucine) 101 mg,

Oxo-2-phenyl-3-calcium propionate (a-keto analogue of phenylalanine) 68 mg,

Methyl-oxo-2-calcium butyrate (a-keto analogue of valine) 86 mg,

DL-hydroxy-2-calcium methylbutyrate (a-hydroxy analogue of methionine) 59 mg,

L-lysine monoacetate 105 mg,

L-threonine 53 mg,

L-tryptophan 23 mg,

L-histidine 38 mg,

L-tyrosine 30 mg;

Excipients:

corn starch,

polyvinylpyrrolidone,

talc,

colloidal silicon dioxide,

magnesium stearate,

polyethylene glycol 6000,

polyvinylpyrrolidone, soluble;

Shell:

talc,

polyethylene glycol 6000,

quinoline yellow (E104),

Eudragit E125,

triacetin,

titanium dioxide

Contraindications

hypersensitivity;
violation of amino acid metabolism;
hypercalcemia.

For hereditary phenylketonuria, it should be taken into account that the drug contains phenylalanine.

Side Effects

In some cases, hypercalcemia may develop.

In this case, it is recommended to reduce vitamin D intake. If hypercalcemia persists, reduce the dose of Ketosteril®, as well as other sources of calcium.

Interaction

With the simultaneous administration of drugs containing calcium, it is possible to increase the level of calcium in the blood serum.

As uremic symptoms decrease under the influence of Ketosteril, the dose of simultaneously used aluminum hydroxide should be reduced accordingly.

In order not to interfere with absorption in the intestines, you should not take drugs that form poorly soluble compounds with calcium (for example, tetracyclines, quinolones, drugs containing iron, fluorine and estramustine) simultaneously with Ketosteril.

There should be an interval of at least 2 hours between taking Ketosteril and similar drugs.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Binnopharm, Russia