Ketorolac-Solopharm, 30 mg/ml 1 ml 10 pcs

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Before prescribing the drug, it is necessary to find out about previous allergy to ketorolac or other NSAIDs. Due to the risk of allergic reactions, the first dose should be administered under close medical supervision. Hypovolemia increases the risk of nephrotoxic adverse reactions. If necessary, it may be used with opioid analgesics.

It is not recommended to use as an agent for premedication, maintenance of anesthesia. When co-administered with other NSAIDs, fluid retention, decompensation of cardiac activity, increased blood pressure may be observed. The risk of drug complications increases with prolongation of treatment (in patients with chronic pain) and increasing of the drug dose. Antacids, misoprostol, omeprazole are used to reduce the risk of NSAID gastropathy.

Impact on driving and operating machinery

When using the drug, caution must be exercised while driving motor vehicles and engaging in potentially hazardous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

– anamnestic evidence of an attack of bronchoobstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs (complete or incomplete combination of bronchial asthma, polyposis of the nose and sinuses and intolerance to acetylsalicylic acid and other NSAIDs);

– hypovolemia (regardless of the cause);

– gastrointestinal erosive-ulcerative lesions with acute conditions, peptic ulcers, bleeding or high risk of bleeding, hypocoagulation (including hemophilia), inflammatory bowel disease (Crohn’s disease, ulcerative colitis);

– Severe hepatic impairment or active liver disease;

– Severe renal impairment (serum creatinine > 700 μmol/L), advanced renal disease;

– confirmed hypokalemia;

– decompensated heart failure, post aortocoronary bypass;

– The drug is not to be used for pain relief before and during surgical interventions due to the high risk of bleeding;

– intracranial hemorrhage or suspected bleeding;

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– confirmed hyperkalemia;

– pregnancy, childbirth, breastfeeding period;

– children under 16 years of age (effectiveness and safety not established).

With caution

Hypersensitivity to other NSAIDs, bronchial asthma, presence of factors that increase gastrointestinal toxicity (alcoholism, smoking, cholecystitis); postoperative period; chronic heart failure (CHF), coronary heart disease (CHD), edema syndrome, arterial hypertension; moderate renal failure (serum creatinine 300-700 μmol/L); cholestasis; sepsis; systemic lupus erythematosus; concurrent use with other NSAIDs, long-term use of NSAIDs; cerebrovascular disease; dyslipidemia, hyperlipidemia, diabetes, peripheral artery disease; history of peptic ulcers, presence of H. pylori; severe somatic diseases; systemic connective tissue diseases; inflammatory bowel disease without exacerbation; concomitant use of oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline), older age (over 65 years).

Side effects

Overdose

Symptoms: abdominal pain, nausea, vomiting, gastrointestinal erosive and ulcerative lesions, impaired renal function, metabolic acidosis.

Treatment: there is no specific antidote, gastric lavage, administration of adsorbents (activated charcoal) and symptomatic therapy (maintenance of vital body functions) are recommended. Ketorolac is not eliminated sufficiently by dialysis.

Pregnancy use

Do not take the drug during pregnancy (adverse effect on the cardiovascular system of the fetus – premature closure of the arterial duct), during childbirth, in the early postpartum period (inhibits the synthesis of prostaglandins, the drug may adversely affect the fetal circulation and weaken uterine contractility, which increases the risk of uterine bleeding) and during breast-feeding (the drug enters the breast milk).

If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Similarities