Ketoconazole DC, tablets 200 mg 10 pcs

Ketoconazole DC is an antifungal agent and is active against dermatophytes, yeasts, dimorphic fungi and eumycetes.

It is also active against staphylococci and streptococci.

The mechanism of action is to inhibit the synthesis of ergosterol of fungi.

Prevents the transformation of Candida albicans blastospores into invasive forms.

Indications

It is used to treat the following diseases:

Active ingredient

Composition

1 tablet contains:

the active ingredient:

ketoconazole 200 mg,

excipients:

Lactose 40 mg,

Corn starch 25 mg,

Pregelatinized starch 12 mg,

microcrystalline cellulose 7.5 mg,

polyvinylpyrrolidone 12.5 mg,

magnesium stearate 5 mg,

sodium starch glycolate 10 mg

How to take, the dosage

Adults – 3.3-6.6 mg/kg of weight per day.

In children – 1-2 tablets a day.

The course of treatment is from two weeks to several months.

Interaction

In concomitant use of ketoconazole with rifampicin and isoniazid a decrease in plasma concentrations of ketoconazole is noted.

In concomitant use of ketoconazole with cyclosporine, indirect anticoagulants and methylprednisolone an increase in their plasma concentrations is possible.

Special Instructions

The liver condition should be monitored during long-term use.

In case of liver disease, the drug should be stopped.

Prednisone should be used with caution in children: long-term use causes inhibition of cortisol synthesis and vitamin D metabolism.

Contraindications

Side effects

Temporary decrease in plasma levels of testosterone.

In rare cases nausea, constipation, stomach pain, flatulence, gastrointestinal bleeding, diarrhea, headache, dizziness occur.

Similarities