Iriten 20 mg/ml 15 ml

Locally advanced or metastatic colorectal cancer:

Monotherapy or in combination with capecitabine in patients with disease progression after conventional treatment.

– in combination with 5-fluorouracil and calcium folinate in patients who have not previously received chemotherapy;

Active ingredient

Composition

1 ml contains irinotecan hydrochloride trihydrate 20 mg

How to take, the dosage

In/v. The drug is intended for adults only.

Iritene is given as an IV infusion of at least 30 minutes and no longer than 90 minutes.

The specific literature should be consulted when choosing the dose and mode of administration for each individual case.

Special Instructions

Iriten should be treated in specialized chemotherapy departments under the supervision of a physician experienced in working with antitumor drugs.

Contraindications

Side effects

Acute cholinergic syndrome occurs in 9% of patients during the first 24 hours after administration of Iriten and is manifested by diarrhea, abdominal pain, increased sweating, miosis, visual disturbances, lacrimation, salivation, decreased blood pressure, dizziness, chills and general malaise.

CNS disorders: involuntary muscle twitching or convulsions, paresthesias, asthenia.

Hematopoietic organs: neutropenia is observed in an average of 80% of patients, including half of them have decreased neutrophils to

In the digestive system: late-onset diarrhea that occurs more than 24 hours (5 days on average) after drug administration is a dose-limiting toxic manifestation and is seen in approximately 87% of patients, of which 38% are severe. Nausea and vomiting usually occur on the first day of administration or 24 h later in 85% of patients. Dehydration against the background of vomiting and diarrhea has been reported, very rarely with the development of renal failure, hypotension and heart failure. Abdominal pain, anorexia, mucositis, constipation are possible.

Allergic reactions: rare – skin rash and very rare – development of anaphylactic shock.

Other: shortness of breath, alopecia, increased body temperature, local reactions.