Iprozhin, capsules 200 mg 15 pcs

Iprozhin is a progestogen, a corpus luteum hormone. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus where, by activating DNA, it stimulates RNA synthesis.

Promotes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone to the secretory phase, and after fertilization – to the state necessary for the development of a fertilized egg.

Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal,
elements of the mammary gland.

By stimulating protein lipase, it increases fat reserves, increases glucose utilization, increases the concentration of basal and stimulated insulin, promotes the accumulation of glycogen in the liver, increases the production of aldosterone; in small doses it accelerates, and in large doses it suppresses the production of gonadotropic hormones of the pituitary gland; reduces azotemia, increases the excretion of nitrogen in the urine. Activates the growth of the secretory part of the acini of the mammary glands and induces lactation. Promotes the development of normal endometrium.

Pharmacokinetics

When taken orally, it is well absorbed in the gastrointestinal tract, the time to reach Cmax is 1-3 hours. After taking 200 mg, the plasma progesterone concentration increases from 0.13 ng / ml to 4.25 ng / ml after 1 hour and is 11.75 ng / ml after 2 hours, 8.37 ng / ml – after 3 hours, 2 ng / ml – after 6 hours, 1.64 ng / ml – after 8 hours.

With intravaginal application, it is rapidly absorbed, a high concentration of progesterone in plasma is observed after 1 hour. The time to reach Cmax is 2-6 hours. With the introduction of 100 mg 2 times / day, the average concentration is 9.7 mg / ml for 24 hours. With the introduction of more than 200 mg the concentration of progesterone corresponds to the first trimester of pregnancy. Communication with plasma proteins – 90%.

Metabolized in the liver with the participation of the CYP2C19 enzyme system. The main metabolites are 20-alpha-hydroxy-delta-4-alpha-pregnanolone and 5-alpha-dihydroprogesterone. Excreted by the kidneys – 50-60%.

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How to take, course of administration and dosage