Iodopyron, 1% 100 ml

Iodopyron is an antiseptic, when used topically it has bactericidal (against a wide range of Gram-positive and Gram-negative microorganisms, including antibiotic-resistant strains of E. coli, Staphylococcus aureus and Proteus), fungicidal and anti-inflammatory effects.

Elemental iodine has pronounced antimicrobial properties. Elemental iodine preparations are characterized by a pronounced local irritating effect on tissues, and in high concentrations – a cauterizing effect. Local action is due to the ability of elemental iodine to precipitate tissue proteins. Preparations that detach elemental iodine have much less pronounced irritating effect, and iodides have local irritating properties only in very high concentrations.

The nature of the resorptive action of preparations of elemental iodine and iodides is the same. Iodine preparations have the most pronounced resorptive effect on thyroid function. In case of iodine deficiency, iodides help to restore the disturbed synthesis of thyroid hormones. With normal levels of iodine in the environment, iodides inhibit the synthesis of thyroid hormones, reducing the sensitivity of the thyroid gland to pituitary TTH and blocking its secretion by the pituitary gland.

The effect of iodine preparations on metabolism is manifested by increased dissimilation. In atherosclerosis they cause a slight decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, they increase fibrinolytic and lipoproteinase activity of blood serum and slow down the rate of blood clotting.

The accumulation of iodine in syphilitic gummas promotes their softening and resorption. However, iodine accumulation in tubercular foci leads to an intensification of the inflammatory process in them. Iodine release by excretory glands is accompanied by irritation of glandular tissue and increased secretion. This causes expectorant action and stimulation of lactation (in small doses). However, in high doses iodine preparations may cause suppression of lactation.

Pharmacokinetics

On contact with skin or mucous membranes, 30% is converted to iodides and the rest to active iodine. It is partially absorbed. The absorbed part penetrates into tissues and organs, is selectively absorbed by the thyroid gland. It is excreted mainly by the kidneys, intestines, sweat and mammary glands.

Indications

For external use: infectious-inflammatory skin lesions, injuries, wounds, myalgias.

For local use: chronic tonsillitis, atrophic rhinitis, purulent otitis, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degree.

For oral use: prevention and treatment of atherosclerosis, tertiary syphilis.

Active ingredient

Composition

Active substances:

Iodine 14.1 g;

Excipients:

potassium iodide 13.8 g,

povidone low molecular weight 122.1 g,

purified water up to 1000 ml

How to take, the dosage

Iodine is used externally to treat damaged skin.

For oral administration the dose is set individually, depending on the indication and age of the patient.

Topically it is used for lacunae and supratonsillar spaces washing – 4-5 applications with 2-3 days intervals, for nasopharyngeal irrigation – 2-3 times a week for 2-3 months, for ear drops and flushing – for 2-4 weeks; in surgical practice and for burns the gauze cloths put on the affected surface are moistened as needed.

Interaction

Pharmaceutically incompatible with essential oils, ammonia solutions, white sediment mercury (an explosive mixture is formed). Alkaline or acidic environment, the presence of fat, pus, blood weaken the antiseptic activity.

It weakens the hypothyroid and strumogenic effects of lithium preparations.

Special Instructions

Iodism phenomena are possible with long-term use.

In case of nephritis and nephrosis it is contraindicated for oral administration.

Contraindications

Individual intolerance to iodine.

Internal administration – pulmonary tuberculosis, nephritis, nephrosis, adenomas (including thyroid), furunculosis, acne, chronic pyoderma, hemorrhagic diathesis, urticaria, pregnancy, children under 5 years.

Side effects

When used externally: rarely – skin irritation; with prolonged use on extensive wound surfaces – iodism (rhinitis, urticaria, Quincke’s edema, salivation, lacrimation, acne).

In oral administration: skin allergic reactions, tachycardia, nervousness, sleep disorders, increased sweating, diarrhea (in patients over 40 years).