Iodilife, tablets 28 pcs

Pharmacological group

ATC code: A11E

B vitamins + other drugs

Pharmacological action

Folic acid refers to B vitamins. In the body, folic acid is reduced to tetrahydrofolic acid, which is involved in the synthesis of purines and pyrimidines, choline metabolism, in general – in the metabolism of nucleic acids and proteins. It plays an important role in the formation of the central nervous system, which develops in humans on day 15-28 after fertilization. Deficiency of folic acid causes the development of neural tube defects in the fetus.

Vitamin B12 exists inside the cell as two active coenzymes: methylcobalamin and adenosylcobalamin. Methylcobalamin is essential for methionine synthetase, which is involved in the metabolism of folic acid. This interaction of folic acid with cobalamin is necessary for normal synthesis of purines and pyrimidines, and therefore DNA. In vitamin B12 or folic acid deficiency, reduced synthesis of methionine and S-adenosylmethionine impairs many methylation reactions, protein and polyamine synthesis.

400 micrograms of folic acid is the minimum effective daily dose recommended by the Centers for Disease Prevention (US, UK and Australia) for healthy women as an additional daily intake to prevent neural tube defects in the fetus. The recommended daily intake of vitamin B12 is 2 micrograms.

Iodine is the basic element for the synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3) (which have an iodine mass fraction of 65% and 59%, respectively). Thyroid hormones are necessary at all stages of life for normal functioning of the central nervous system (CNS).

Pharmacokinetics

Folic acid is rapidly absorbed in the jejunum, undergoing reduction and methylation to 5-methyltetrahydrofolate. The maximum concentration in plasma is observed after 30-60 minutes.

It binds intensively with plasma proteins. It penetrates through the blood-brain barrier, into the placenta and the breast milk. It is excreted by the kidneys mainly as metabolites. Vitamin B12 can be absorbed after its interaction in the stomach with intrinsic factor Kahl, a glycoprotein that is secreted by the parietal cells of the stomach. Maximum plasma concentrations are observed after 8-12 hours. As with folic acid, vitamin B12 undergoes significant intestinal-hepatic recirculation.

The average half-life of vitamin B12 is about 6 days. Part of the administered dose is excreted by the kidneys during the first 8 hours, although most is excreted with the bile. 25% is excreted through the intestines. In addition, vitamin B12 passes through the placenta and is present in the mother’s milk.

Vitamin B12 is largely bound to plasma proteins, the excess accumulates in the liver.

Iodine has good absorption. The intestinal absorption rate of iodine after ingestion of water-soluble iodine salts (e.g., potassium iodide) is thought to be 100%. The mechanism of intestinal absorption of iodine is not known.

After completion of the absorption process, iodine spreads rapidly through the intercellular fluid. Iodine penetrates the placental barrier and is present in the mother’s milk. Iodine is transported to other tissues (except thyroid tissue): mammary/salivary gland and intestinal mucosa.

The bulk of iodine is excreted by the kidneys and a small amount with saliva, milk, sweat, bile and through the intestine.

Indications

How to take, the dosage

Interaction

Special Instructions

Contraindications

Individual hypersensitivity to the ingredients of the drug, lactation, pediatric age.

The drug contains lactose. The drug is contraindicated in patients with hereditary galactose intolerance, lactase deficiency or disorders of glucose or galactose absorption.

At a daily dose of more than 150 mg/day, potassium iodide is contraindicated in patients with acute bronchitis, severe and latent hyperthyroidism.

With caution

Patients with: hypocomplementemic vasculitis, goiter or autoimmune thyroiditis, kidney disease, chronic hyperkalemia, active tuberculosis, epilepsy are cautionary patients.

Overdose

Pregnancy use