Intraject 2.2% 2 ml

INTRAGEKT® is a sterile, colorless, transparent, homogeneous, viscous gel without mechanical impurities obtained by bacterial fermentation. INTRAGEKT® contains no animal proteins and does not require a prior allergy test. Hyaluronic acid is a natural glycosaminoglycan of intercellular matrix having the greatest hygroscopic properties of all known natural mucopolysaccharides.

Mechanism of action.

Hyaluronic acid is a natural polysaccharide belonging to the class of glycosaminoglycans that is a component of all body tissues and is the most important structural element of synovial fluid. Hyaluronic acid is unmodified.

The product INTRAJECT® contains:

– sodium salt of hyaluronic acid and water, whose molecules form hydrogen bonds due to the presence

– in the molecular structure of hydroxyl groups (OH-groups), as well as the presence of a large number of nitrogen oxygen atoms in the hyaluronic acid molecule. Due to the formation of hydrogen bonds with water molecules, hyaluronic acid has a high ability to bind and retain water, acquiring a gelatinous structure.

Macromolecules of hyaluronic acid, due to the same mechanisms, form intramolecular and intermolecular interactions, giving a fairly stable three-dimensional structure.

The INTRAGEKT® product has an ordered gel structure able to retain hyaluronic acid and water molecules inside the synovial pouch providing stability of the INTRAGEKT® product which guarantees its prolonged action.

The viscoelastic properties of hyaluronic acid, a component of synovial fluid, provide lubrication and cushioning of articular surfaces. Synovial fluid in the joints in degenerative diseases (osteoarthritis) or traumatic changes in the joints, has lower viscosity and elasticity than in healthy joints. Hyaluronic acid, a component of INTRAGEKT®, has a molecular weight of 2.2 million daltons, close to natural human hyaluronic acid, and has a positive effect after injection in the diagnosis of osteoarthritis (osteoarthritis). Intra-articular injection of INTRAJECT® restores physiological and rheological properties of synovial fluid of the joint affected by osteoarthritis. As a consequence, pain and discomfort decrease and mobility in the joints improves.

Biodegradation of the medical product in the patient’s body.

Complete biodegradation in the body occurs after 6 months. In the course of movement hyaluronates enter the lymphatic system of the joint capsule, enter the general bloodstream and are eventually absorbed by the liver where they degrade to water and carbon dioxide The product INTRAJECT® has no metabolic effects on the body. Once administered, INTRAJECT® should not be withdrawn or replaced.

Indications

Active ingredient

Interaction

Contraindications

Side effects