Ibuklin Junior, 100 mg+125 mg 20 pcs

Pharmacodynamics

Combined drug, the action of which is due to its constituent components.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), has analgesic, anti-inflammatory, antipyretic effect.
Inhibiting cyclooxygenase (COX) 1 and 2, disrupts arachidonic acid metabolism, reduces the number of prostaglandins (mediators of pain, inflammation and hyperthermia) both in inflammation focus and in healthy tissues, inhibits the exudative and proliferative phases of inflammation.

Paracetamol inhibits COX indiscriminately, mainly in the central nervous system, slightly affects the water-salt metabolism and the mucosa of the gastrointestinal tract (GIT). It has analgesic and antipyretic effect.
In inflamed tissues peroxidase neutralizes the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.
The effectiveness of the combination is greater than that of the individual components.

Pharmacokinetics

Ibuprofen.

Absorption is high, rapidly and almost completely absorbed from the gastrointestinal tract (GIT).
Time to reach maximal
concentration (TCmax) after oral intake – about 1-2 hours.
Blood plasma protein binding – more than 90%. The half-life (T1/2) is about 2 hours. After absorption about 60% of pharmacologically inactive R-form is slowly transformed into active S-form.
It is metabolized.
More than 90% is excreted by the kidneys (not more than 1% unchanged) and, to a lesser extent, with the bile as metabolites and their conjugates.

Paracetamol.

Absorption is high, binding to plasma proteins is less than 10% and increases slightly in overdose.
Sulfate and glucuronide metabolites do not bind to plasma proteins even in relatively high concentrations.
Cmax is 5-20 mg/ml, TCmax is 0.5-2 hours. It is evenly distributed in the body fluids. A small portion of the drug is hydroxylated by microsomal enzymes to form highly active N-acetyl-n-benzoquinonimine, which binds to sulfhydryl groups of glutathione.
In case of depletion of glutathione reserves in liver (in overdose) enzyme systems of hepatocytes may be blocked resulting in their necrosis.

T1/2 – 2-3 hours. It is excreted by the kidneys, mainly as glucuronide and sulfate conjugates (less than 5% – unchanged).
Less than 1% of the dose of paracetamol is penetrated into the breast milk.
The ability to form conjugates with glucuronic acid in children is lower than in adults.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

In concomitant use of the drug Ibuklin with medicinal products may develop various interaction effects.

Long-term combined use with paracetamol increases the risk of nephrotoxic effects.

Combination with ethanol, glucocorticosteroids, corticotropin increases the risk of gastrointestinal erosive ulcers.

Ibuprofen increases the effect of direct (heparin) and indirect (coumarin and indandion derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplase, streptokinase, urokinase), antiaggregants, colchicine – the risk of hemorrhagic complications increases.

It increases the hypoglycemic effect of insulin and oral hypoglycemic drugs.

Allows the effects of hypotensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).

It increases the blood concentration of digoxin, lithium drugs and methotrexate.

Caffeine increases the analgesic effect of ibuprofen.

Cyclosporine and gold drugs increase nephrotoxicity.

Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin increase the incidence of hypoprothrombinemia.

Antacids and colestiramine decrease absorption of the drug.

Myelotoxic drugs contribute to the manifestation of hematotoxicity of the drug.

Special Instructions

Contraindications

Side effects

Overdose

Symptoms:

Gastrointestinal disturbances (abdominal pain, diarrhea, nausea, vomiting, anorexia, epigastric pain), increased prothrombin time, bleeding after 12-48 h, lethargy, somnolence, depression, headache, tinnitus, impaired consciousness, abnormal heart rhythm, decreased blood pressure, hepato- and nephrotoxicity manifestations, seizures, possible development of hepatonecrosis.

Treatment:

Gastric lavage during the first 4 hours; alkaline drinking, forced diuresis; activated charcoal orally, administration of SH-group donors and precursors of glutathione synthesis – methionine 8-9 h after overdose and N-acetylcysteine orally or intravenously – after 12 h., antacids; hemodialysis; symptomatic therapy.

The need for additional therapeutic measures (further methionine administration, intravenous N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Pregnancy use

Ibuklin Junior is not recommended for children under 3 years of age,

pregnant and lactating.

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