Hyalurome, 15 mg/ml 2 ml syringe

The solution for intra-articular injection of HIALUROM – 1.5% solution of sodium hyaluronate in 2 ml disposable syringes is a sterile, viscoelastic solution of sodium hyaluronate.

Sodium Hyaluronate is obtained by fermentation. Sodium Hyaluronate HIALUROM is a polysaccharide identical to human, consisting of repeating disaccharide links of N-acetylglycosamine and sodium glucuronate, with a molecular weight greater than 2,400,000 Da. Sodium hyaluronate is ubiquitous in the human body and is present in high concentrations in tissues such as the vitreous, synovial fluid, umbilical cord and dermis.

In the synovial fluid, sodium hyaluronate acts as a lubricant and shock absorber, which promotes normal movement without pain. In disease such as arthritis, the viscoelasticity of synovial fluid decreases, so that it greatly increases the mechanical stress on the joint and increases the destruction of articular cartilage, manifested by restriction and pain when moving in the joints.

The lubricating and cushioning effects of this drug alleviate pain and improve joint mobility when used intra-articularly. These effects last for more than 6 months after a single course of treatment.

Indications

GIALUROM solution is used as a viscoelastic supplement to replace synovial fluid in pain caused by degenerative synovial joint diseases such as osteoarthritis or osteoarthritis. HIALUROM acts as a lubricant and mechanical support for the diseased joint. HIALUROM solution is injected into human joints:

Active ingredient

Composition

Active ingredients:

Sodium hyaluronate,

Sodium chloride,

water for injection

How to take, the dosage

Injections of HIALUROM are performed by specialist physicians.

Hialurom solution is intended for intra-articular use only. It is not used intravenously. Sodium hyaluronate is injected at room temperature. The injected volume depends on the size of the joint, but does not exceed 2 ml for the knee joint and other large joints, or 1 ml for small joints. The physician is responsible for setting the applicable volume and must make sure that the joint is not overloaded.

The GIALUROM solution is injected into the joint cavity once a week for 3 consecutive weeks. Simultaneous treatment of several joints is possible. The treatment cycle should not be repeated earlier than 6 months for the same joint. Before using Gialurom, fluid accumulation in the joint should be removed by sucking it out with a syringe.

GIALUROM solution is available as a pre-filled syringe which does not need to be diluted. The product is sterile and should be used immediately after opening the package. The drug is intended for single use only. GIALUROM must be administered carefully into the joint cavity, following the administration route carefully. Injection is an aseptic procedure, so observe appropriate precautions. The ready syringe is removed from the sterile case, the cap is removed, and then the sterile needle is put on, which is fixed with a slight twist. The air must be removed from the syringe before insertion.

Contraindications

Side effects

Sodium Hyaluronate has excellent tolerability.

Possible local secondary phenomena such as pain, a feeling of warmth, redness and swelling may be observed on the joint into which the drug is injected (application of ice on the joint for five to ten minutes will remove all such phenomena).

Allergic reactions may be extremely rare.

There are minimal risks associated with infection and bleeding when administered intra-articularly.

Similarities