Human leukocyte interferon 1000 IU

Interferon alpha is a mixture of different subtypes of natural alpha-interferon from human blood leukocytes. It has antiviral, immunostimulatory and antiproliferative effects. The antiviral action of the drug is mainly based on increasing the resistance of the body cells that have not yet been infected by the virus to the possible effects. Being bound with specific receptors on cell surface, interferon alfa changes cell membrane properties, stimulates specific enzymes, affects RNA of virus and prevents its replication. Immunomodulatory effect of interferon alfa is associated with stimulation of macrophages and NK (natural killer) cells activity, which in their turn participate in the immune response of the body to tumor cells.

Indications

Preventing and treating influenza and other acute respiratory viral infections.

Active ingredient

Composition

The solution for topical application and inhalation

Active ingredient:leukocytic human interferon 1000 ME.

How to take, the dosage

For prevention of influenza and other acute respiratory viral infections, the drug is administered by spraying or injecting an aqueous solution. Injection of the drug by injection is strictly prohibited. Containers with the drug should be opened immediately before use. Opened ampoule with the drug can be stored at 2 to 10 ° C for no more than 24 hours. The drug can be sprayed with a nebulizer of any system. 0.25 ml of the solution should be injected into each nasal passage twice a day with an interval of at least 6 hours. When injecting the drug, 5 drops should be administered into each nasal passage 2 times a day at intervals of at least 6 hours. When treating, the drug is used by inhalation, nebulization or injection. The most effective method is inhalation. For its implementation, inhalers equipped with electric heating or other systems are recommended. Three vials of the drug should be used for one injection. Water should be heated to a temperature no higher than 37 ° C. The drug shall be administered by inhalation twice a day with an interval of at least 6 hours. If the drug is applied by injection, 0.25 ml (5 drops) is injected into each nasal passage every 1-2 hours, at least 5 times a day for 2-3 days. Adults and children are prescribed the drug in the same dose.

Interaction

Because interferons inhibit oxidative metabolism in the liver, the biotransformation of drugs metabolized by this route may be impaired.

In concomitant use with ACE inhibitors synergism is possible with regard to hematotoxic action; with zidovudine – synergism with regard to myelotoxic action; with paracetamol – possible increase in activity of liver enzymes; with theophylline – decrease of theophylline clearance.

Contraindications

Hypersensitivity to the ingredients of the drug, severe heart disease (including history), acute myocardial infarction, severe liver, renal or hemopoietic system disorders, epilepsy and/or other CNS disorders; chronic hepatitis

Side effects

Lethargy, fever, chills, loss of appetite, muscle pain, headache, joint pain, sweating, nausea, vomiting, change in taste sensation, dry mouth, weight loss, diarrhea, abdominal pain, constipation, flatulence, increased peristalsis, heartburn, liver dysfunction, hepatitis, dizziness, visual disturbances, ischemic retinopathy, depression, drowsiness, impaired consciousness, nervousness, sleep disorders, skin allergic reactions (rash, itching).