Heparin ointment, ointment 25 g

A combination drug for external use, the action of which is due to the properties of its constituent components. It is a direct acting anticoagulant. Sodium heparin gradually released from the ointment reduces inflammation and has an antithrombotic effect. Promotes the resorption of existing clots and prevents the formation of new ones. It blocks the synthesis of thrombin, reduces platelet aggregation. Inhibits the activity of hyaluronidase and activates the fibrinolytic properties of the blood.

Benzylnicotinate has a vasodilator and antispasmodic effect. It directly reduces the contractile activity of the smooth muscles of blood vessels and internal organs. Benzylnicotinate, by dilating surface vessels, promotes absorption of heparin.

The local antiseptic benzocaine (anastesine), reducing the permeability of the cell membrane to sodium ions, blocks the conduction of nerve impulses. It prevents the occurrence of pain impulses in the endings of sensitive nerves and their conduction along the nerve fibers, reduces the severity of pain sensations. When applied to the skin it has a local analgesic effect.

Pharmacokinetics

When applied topically, only a small amount of sodium heparin is absorbed into the systemic circulation and is excreted mainly by the kidneys.

The pharmacokinetics of the active substances benzyl nicotinate and benzocaine (anastesine) have not been studied with local administration.

Indications

Active ingredient

Composition

Active ingredients:

Heparin sodium – 10000 IU (0.83 g),

Benzocaine (anastesin) – 4.0 g,

Benzylnicotinate – 0.08 g.

Auxiliary substances: glycerol – 15,0 g, Vaseline – 6,0 g, stearic acid – 5,0 g, corn oil – 5,0 g, emulsifier №1 – 8,0 g, methyl parahydroxybenzoate – 0,148 g, propyl parahydroxybenzoate – 0,048 g, purified water – up to 100,0 g.

How to take, the dosage

Externally. The ointment is applied thinly to the affected area and gently rubbed into the skin, without massaging, 2 – 3 times a day until the disappearance of inflammation, on average 3 to 14 days. Maximum daily dose of the drug is 25.0 g. The possibility of a longer course of treatment is determined by the doctor.

In case of thrombosis of external hemorrhoidal nodes, rectal swabs soaked in the ointment are used and inserted into the anus. Or the ointment is applied to a cloth or linen pad, which is placed directly on the thrombosed knots and fixed. The ointment should be used daily until symptoms disappear, on average 3 to 14 days.

In case of trophic ulcers of the shin, the ointment is applied only to the surrounding skin areas with intact skin integrity.

Interaction

Special Instructions

The ointment should not be applied to open wounds, mucous membranes, in the presence of purulent processes on the skin. Use of the drug is not recommended in case of deep venous thrombosis.

Long-term use of heparin requires control of the clotting time.

Long-term use of benzylnicotinate requires control of liver function and total blood count.

Influence on ability to drive vehicles, machinery

The drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities requiring increased concentration and rapid psychomotor reactions.

Synopsis

Contraindications

Hypersensitivity to the components of the drug, childhood, ulcerative – necrotic processes in thrombophlebitis, reduced blood clotting, thrombocytopenia, violation of the integrity of the skin (due to the possibility of increased bleeding).

Sodium heparin is contraindicated in cases of hemorrhagic diathesis, leukaemia, anemia, high permeability of blood vessels, polyps, malignant tumours and gastrointestinal ulcers, severe liver and kidney function disorders, brain and spinal operations.

Benzylnicotinate is contraindicated in paroxysmal tachycardia.

Benzocaine (anastesine) is contraindicated in hypersensitivity to this drug.

Cautions

Cautious use of heparin is required for ulcerative and tumorous lesions of the gastrointestinal tract, cachexia, high blood pressure, in the immediate postpartum and postoperative period (during the first 3 to 8 days).

The limitation to the use of benzyl nicotinate is adenoma of the prostate gland with impaired urine flow.

Limitations to the use of benzocaine (anastesine) are: breastfeeding (should be suspended), infant age (under 1 year).

Side effects

Allergic reactions – skin rash, angioedema – are possible. If such symptoms occur, the drug should be discontinued and desensitizing drugs should be prescribed.

When using heparin it is necessary to consider the possibility of hemorrhages. Along with hemorrhages the use of heparin may lead to the development of thrombocytopenia, osteoporosis, alopecia and hypoaldosteroidism.

When using benzyl nicotinate a transient increase in liver transaminase activity, tachycardia, leukopenia and sometimes impaired renal function may occur.

In the use of benzocaine (anesthesin), contact dermatitis may occur occasionally; decreased sensitivity at the site of use; rarely, with excessive use, methemoglobinemia (especially in infants and young children).

Overdose

Pregnancy use

The use of the drug during pregnancy and during breast-feeding is possible only under strict indications and close medical supervision.

The drug is not indicated in the immediate postpartum period (during the first 3 to 8 days) due to the possibility of increased bleeding as a result of heparin sodium and benzyl nicotinate.

Breast-feeding should be suspended if the use of the drug is necessary during this period (due to the presence of benzocaine (anastesine).

Similarities