Hemodez-N, 400 ml

The action of the drug is due to the ability of low-molecular polyvinylpyrrolidone to bind toxins circulating in blood and quickly remove them from the body. It most completely binds toxins circulating in the blood of patients with dysentery, salmonellosis, food intoxications. In burn disease toxins formed during the first 4-5 days of the disease are almost completely inactivated; toxins formed in later periods are much weaker neutralized.

Toxins produced in patients during acute radiation disease are not bound, although it is possible to accelerate their removal from the body.

The drug helps eliminate stasis of red blood cells in the capillaries, developing in intoxication of any origin, which leads to improved microcirculation. It enhances renal blood flow, increases glomerular filtration and increases diuresis. The drug is non-toxic and has no antigenic and pyrogenic properties. The reduction of the molecular weight of the polymer accelerates its excretion by the kidneys and improves the detoxification properties of the drug.

Pharmacokinetics

It is not metabolized in the body. It is rapidly excreted by the kidneys, within 4 hours – 80%, after 12-24 hours – completely.

Indications

— shock (post-traumatic, postoperative, burn, hemorrhagic);

– intoxication (toxic diseases of the gastrointestinal tract, including dysentery, dyspepsia, salmonellosis; burn, radiation and hemolytic disease, peritonitis, intestinal obstruction, thyrotoxicosis, liver disease, sepsis, pneumonia; acute phase of myocardial infarction);

— toxemia of newborns;

– gestosis.

Pharmacological effect

The effect of the drug is due to the ability of low molecular weight polyvinylpyrrolidone to bind toxins circulating in the blood and quickly remove them from the body. Most completely binds toxins circulating in the blood of patients with dysentery, salmonellosis, and food intoxication. In case of burn disease, toxins formed in the first 4-5 days of illness are almost completely inactivated; toxins formed at a later date are neutralized much less effectively.

Toxins formed in the body of patients with acute radiation sickness are not bound, although it is possible to accelerate their elimination from the body.

The drug helps eliminate stasis of red blood cells in capillaries, which develops during intoxication of any origin, which leads to improved microcirculation. Increases renal blood flow, increases glomerular filtration and increases diuresis. The drug is non-toxic, does not have antigenic or pyrogenic properties. Reducing the molecular weight of the polymer accelerates its excretion from the body by the kidneys and improves the detoxification properties of the drug.

Pharmacokinetics

It is not metabolized in the body. It is quickly excreted by the kidneys, within 4 hours – 80%, after 12-24 hours – completely.

Special instructions

For extensive burns, it is combined with the administration of plasma, albumin, and gamma globulin.

Before starting the infusion, check the expiration date of the package. The preparation must be transparent and free of suspended matter, sediment and mold. By pressing the container with the drug, check its tightness and integrity of the packaging. The results of the visual examination are recorded in the medical history. During treatment, monitoring of blood pressure and the patient’s condition is necessary.

Before administration, the solution is warmed to body temperature.

Active ingredient

Povidone

Composition

povidone (polyvinylpyrrolidone) low molecular weight medical with molecular weight 8000±2000 6 g

sodium chloride 550 mg

potassium chloride 42 mg

calcium chloride 50 mg

sodium bicarbonate 23 mg

magnesium chloride anhydrous 500 mcg

Excipients: water for injection.

Contraindications

– intracranial hypertension;

– hemorrhagic stroke;

— condition after traumatic brain injury;

— chronic heart failure stage IIb-III;

– respiratory failure;

– severe allergic reactions;

– thromboembolism;

– oliguria, anuria, acute nephritis;

– bronchial asthma;

– phlebothrombosis;

– hypersensitivity.

Side Effects

Decreased blood pressure, tachycardia, difficulty breathing (with rapid administration), allergic reactions of varying severity (up to the development of anaphylactic shock). Injection site infection, thrombosis, or phlebitis extending from the infusion site.

Manufacturer

Eskom NPK, Russia