Hartil, tablets 5 mg 28 pcs

Hartil is an antihypertensive drug, an ACE inhibitor. As a result of suppression of ACE activity (regardless of plasma renin activity), a hypotensive effect is developed (in the prone and standing position) without a compensatory increase in HR. Suppression of ACE activity increases plasma renin activity and decreases angiotensin II and aldosterone levels. Ramipril acts on ACE circulating in blood and in tissues, including the vascular wall. It decreases OPPS (post-load), pulmonary capillary pressure (preload), increases cardiac output and increases exercise tolerance.

Indications

Active ingredient

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Cardiovascular system: BP decrease, orthostatic hypotension, tachycardia; rarely – arrhythmia, increased blood supply disorders of organs caused by blood vessel narrowing. In excessive BP reduction, mainly in patients with CHD and clinically significant cerebral vasoconstriction, myocardial ischemia (angina or myocardial infarction) and cerebral ischemia (possibly with dynamic cerebral circulation disorder or stroke) may develop.

Urogenital system disorders: development or exacerbation of renal failure, exacerbation of existing proteinuria, decrease in urine volume (at the beginning of the drug).

CNS disorders: dizziness, headache, weakness, somnolence, paresthesias, nervous excitability, restlessness, tremor, muscle spasm, mood disorders; when used in high doses – insomnia, anxiety, depression, confusion, fainting.

Sensory organs: vestibular disorders, disorders of taste (e.g. metallic taste), smell, hearing and vision, tinnitus.

Digestive system disorders: nausea, vomiting, diarrhea or constipation, epigastric pain, dry mouth, thirst, decreased appetite, stomatitis, hypersensitivity or mucous membrane inflammation of the cheeks, pancreatitis; rarely – hepatitis, cholestatic jaundice, liver function disorders with development of acute liver failure.

Respiratory system disorders: “dry” cough, bronchospasm (in patients with increased cough reflex), shortness of breath, rhinorrhea, rhinitis, sinusitis, bronchitis.

Allergic reactions: skin rash, pruritus, urticaria, conjunctivitis, photosensitization; rarely – angioedema of the face, extremities, lips, tongue, pharynx or larynx, exfoliative dermatitis, erythema multiforme exudative (including Stevens-Johnson syndrome).Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), pemphigus, serositis, onycholysis, vasculitis, myositis, myalgia, arthralgia, arthritis, eosinophilia.

Hematopoietic organs: anemia, decreased hemoglobin and hematocrit concentrations, thrombocytopenia, leukocytopenia, neutropenia, agranulocytosis, pancytopenia, hemolytic anemia; decrease of erythrocyte number, bone marrow depression is possible.

Overdose

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