Haileflox, 750 mg 5 pcs

Levofloxacin is a synthetic broad-spectrum fluoroquinolone. It inhibits DNA-enzyme (topoisomerase II) and topoisomerase IV, breaks supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, causes profound morphological changes in cytoplasm, cell wall and membranes of sensitive microorganisms.

Levofloxacin is effective against most strains of the following microorganisms:

Aerobic Gram-positive microorganisms – Corynebacterium diphtheriae, Enterococcus spp. (including Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp. (leukotoxin-containing and coagulase-negative methicillin-sensitive/moderately sensitive strains, including methicillin-sensitive strains of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus spp. Streptococcus agalactiae, Streptococcus pyogenes, penicillin-sensitive/moderately sensitive/resistant strains of Streptococcus pneumoniae, penicillin-sensitive/resistant strains of Streptococcus viridans);

aerobic gram-negative microorganisms – Acinetobacter spp. (including Acinetobacter baumanii), Actinobacillus actinomycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter spp. (including Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus spp. (including Haemophilus ducreyi, Haemophilus parainfluenzae, ampicillin-sensitive/resistant strains of Haemophilus influenzae), Helicobacter pylori, Klebsiella spp. (including Klebsiella oxytoca, Klebsiella pneumoniae), Moraxela catarrhalis (beta-lactamase producing and non-producing strains), Morganella morganii, Neisseria spp. Neisseria meningitidis producing and non-producing strains of Neisseria gonorroeae), Pasteurella spp. (including Pasteurella conis, Pasteurella dagmatis, Pasteurella multocida), Proteus spp. (including Proteus mirabilis, Proteus vulgaris), Providencia spp. (including Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (including Pseudomonas aeruginosa), Serratia spp. (including Serratia marcescens), Salmonella spp, Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterum spp., Veilonella spp.;

other microorganisms – Bartonella spp, Chlamydia spp. (including Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis), Legionella pneumophila, Mycobacterium spp. (including Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma spp. (including Mycoplasma hominis, Mycoplasma pneumoniae), Rickettsia spp, Ureaplasma urealyticum.

Resistant microorganisms:

aerobic gram-positive microorganisms – Corynebacterium jeikeium, Staphylococcus spp.(coagulase-negative methicillin-resistant strains, incl. methicillin-resistant strains of Staphylococcus aureus);

aerobic Gram-negative microorganisms – Alcaligenes xylosoxidans;

other microorganisms – Mycobacterium avium.

Indications

Active ingredient

Composition

1 tablet contains:

the active ingredient:

levofloxacin hemihydrate 780.26 mg (corresponding to 750 mg of levofloxacin);

excipients:

Corn starch, 71.96 mg;

MCC, 60.5 mg;

povidone K30 – 7.5 mg;

methyl parahydroxybenzoate – 0.9 mg;

propyl parahydroxybenzoate – 0.18 mg;

Purified talc – 19.5 mg;

Magnesium stearate – 9.6 mg;

sodium carboxymethyl starch – 9.6 mg;

coating film:

Hypromellose; purified talc; macrogol 6000; titanium dioxide; Sunset Yellow dye

How to take, the dosage

Interaction

Special Instructions

Contraindications

With caution – advanced age (high probability of concomitant decreased renal function), glucose-6-phosphate dehydrogenase deficiency.

Side effects

Nervous system disorders: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesias, fear, hallucinations, confusion, depression, motor disorders, seizures.

Sensory organs: disorders of vision, hearing, smell, taste and tactile sensitivity.

Systemic reactions: decreased blood pressure, vascular collapse, tachycardia, prolongation of QT interval, atrial fibrillation.

Digestive system disorders: nausea, vomiting, diarrhea (including blood), digestive disorders, decreased appetite, abdominal pain, pseudomembranous colitis; increased liver transaminases activity, hyperbilirubinemia, hepatitis, dysbiosis.

Metabolic disorders: hypoglycemia (increased appetite, increased sweating, shivering, nervousness).

Muscular system: arthralgia, muscle weakness, myalgia, rhabdomyolysis, tendon rupture, tendinitis.

Urinary system disorders: hypercreatininemia, interstitial nephritis, acute renal failure.

Hematopoietic organs: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhages.

Allergic reactions: itching and hyperemia of the skin, swelling of the skin and mucous membranes, urticaria, erythema malignant exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bronchospasm, choking, anaphylactic shock, allergic pneumonitis, vasculitis.

Others: photosensitization, asthenia, exacerbation of porphyria, persistent fever, development of superinfection.

Overdose

Similarities