Gynofort, vaginal cream 20 mg/g 5 g

Gynofort has fungicidal activity against Candida fungi, Trichophyton, Microsporum, Epidermophyton and some Gram-positive bacteria. It is most effective against candidiasis.

Blocking formation of ergosterol from lanosterol in the cell membrane it increases membrane permeability which leads to lysis of the fungus cell.

Vaginal cream is an emulsion of the water-in-oil type, so it gives the butoconazole carrier a bioadhesive property (bioadhesion leads to increased bioavailability and duration of action of the drug substance).

In intravaginal application butoconazole remains on the vaginal mucosa for 4-5 days.

Indications

Vaginal candidiasis caused by Candida albicans.

Pharmacological effect

Gynofort has fungicidal activity against fungi Candida, Trichophyton, Microsporum, Epidermophyton and some gram-positive bacteria. Most effective for candidiasis.

By blocking the formation of ergosterol from lanosterol in the cell membrane, it increases the permeability of the membrane, which leads to lysis of the fungal cell.

Vaginal cream is a water-in-oil emulsion, therefore it gives the butoconazole carrier a bioadhesive property (bioadhesion leads to an increase in the bioavailability and duration of action of the drug).

When administered intravaginally, butoconazole remains on the vaginal mucosa for 4–5 days.

Active ingredient

Butoconazole

Composition

Active ingredient:

butoconazole nitrate 20 mg;

Excipients:

sorbitol – 399.78 mg;

mineral oil – 80.32 mg;

glyceryl monostearate – 27.13 mg;

polyglyceryl-3-oleate – 27.13 mg;

wax – 4.52 mg;

colloidal silicon dioxide – 10.13 mg;

disodium edetate – 0.5 mg;

methyl parahydroxybenzoate – 1.8 mg;

propyl parahydroxybenzoate – 0.5 mg;

propylene glycol – 50 mg;

water – 378.19 mg

Pregnancy

The drug is contraindicated during pregnancy and lactation.

Contraindications

pregnancy period;
lactation;
hypersensitivity to any of the components of the drug;
children under 18 years of age (efficacy and safety have not been established).

Side Effects

Burning, itching, soreness and swelling of the vaginal wall, pain/spasms in the lower abdomen.

Interaction

Gynofort® cream contains mineral oil, which damages products made of latex or rubber (including condoms or intravaginal diaphragms), therefore, within 72 hours after using the drug Gynofort® it is not recommended to use the above contraceptives. Other methods of contraception should be used.

Storage conditions

At a temperature of 15–25 °C.

Shelf life

3 years

Manufacturer

Gedeon Richter, Hungary