Guttalax, drops 7.5 mg/ml, 15 ml

Guttalax is a laxative drug. The active ingredient, sodium picosulfate, is a laxative of the triarylmethane group.

As a local laxative, sodium picosulfate after bacterial cleavage in the large intestine has a stimulating effect on the mucous membrane of the large intestine, increasing peristalsis, helps to accumulate water and electrolytes in the large intestine. This leads to stimulation of the act of defecation, reduction of evacuation time and softening of stools.

Pharmacokinetics

After oral administration, sodium picosulfate enters the colon. Absorption of the drug is insignificant, which rules out its enterohepatic circulation.

In the colon, sodium picosulfate is broken down to form the active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane. The time of development of the laxative effect of the drug is determined by the rate of release of the active metabolite and is 6-12 hours.

A small part of the drug enters the systemic bloodstream.

There is no correlation between the laxative effect of the active metabolite and its concentration in blood serum.

Indications

Chronic Constipation

Active ingredient

Composition

Active substance:

Sodium picosulfate 7.5 mg;

Supplementary substances:

Sodium methylparaoxybenzoate;

Sorbitol 70%;

Hydrochloric acid;

Purified water.

How to take, the dosage

Guttalax is taken orally, before going to bed.

In adults, the initial dose is 10 drops, with severe and persistent constipation – up to 30 drops.

For children over 4 years of age the initial dose is 5-10 drops.

Depending on the effect obtained, the dose is increased or reduced with subsequent doses.

Interaction

The simultaneous use of Guttalax and diuretics or GCS increases the risk of electrolyte disturbances.

The concomitant administration of broad-spectrum antibiotics may decrease the laxative effect of Guttalax.

Special Instructions

Do not use daily without a doctor’s supervision for more than 10 days.

In children, Guttalax should be prescribed only on the recommendation of a doctor.

Contraindications

Side effects

Diarrhea, abdominal pain, dehydration, disruption of the water-electrolyte balance, weakness, seizures, decreased blood pressure.

Overdose

Symptoms: Diarrhea, abdominal pain, dehydration, impaired water-electrolyte balance, weakness, seizures, decreased blood pressure. In addition, in chronic overdose development of mucosal ischemia of the colon, secondary hyperaldosteronism, urolithiasis, renal tubule damage is possible.

Treatment: Gastric lavage, correction of disorders of water and electrolyte balance, antispasmodic drugs. Glucocorticosteroids, diuretics increase the risk of electrolyte disturbances.

The broad-spectrum antibiotics reduce the laxative effect.

Similarities