Griseofulvin, tablets 125 mg 20 pcs

Griseofulvin is an antifungal antibiotic.

It has fungistatic action.

It is active against dermatophytes of the genera Trichophyton, Microsporum, Epidermophyton.

Inhibits cell division of fungal cells in metaphase by disrupting the structure of the mitotic spindle.

Friseofulvin accumulates to varying degrees in skin, hair and nail cells that are precursors of keratin, making keratin resistant to fungal invasion.

As infected keratin separates, it is replaced by healthy tissue.

Indications

Mycoses of skin, hair and nails, etc.

Pharmacological effect

Griseofulvin is an antifungal antibiotic.

Has a fungistatic effect.

Active against dermatophytes of the genera Trichophyton, Microsporum, Epidermophyton.

Inhibits cell division of fungal cells in metaphase, disrupting the structure of the mitotic spindle.

Griseofulvin accumulates to varying degrees in skin, hair and nail cells, which are the precursors of keratin, making keratin resistant to fungal invasion.

As the infected keratin is shed, it is replaced with healthy tissue.

Special instructions

Treatment with Griseofulvin is carried out under the control of the morphological composition of the blood (once every 10-15 days).

Active ingredient

Griseofulvin

Composition

Active ingredient:

griseofulvin 125 mg.

Contraindications

Hypersensitivity, systemic lupus erythematosus, liver and kidney diseases.

Side Effects

From the central nervous system: headache, dizziness, disorientation, unusual fatigue or weakness, insomnia, peripheral neuropathy, impaired coordination of movements, paresthesia of the extremities, confusion.

From the gastrointestinal tract: nausea, vomiting, diarrhea, gastralgia, candidal stomatitis, hepatitis.

From the hematopoietic organs: granulocytopenia, agranulocytosis, leukopenia.

Allergic reactions: urticaria, skin rash, itching, angioedema, photosensitivity, lupus-like syndrome, erythema multiforme, Lyell’s syndrome.

Interaction

Enhances the effect of ethanol.

Reduces the activity of estrogen-containing oral contraceptives, indirect anticoagulants (due to the induction of microsomal liver enzymes).

Barbiturates and primidone reduce antifungal activity.

Storage conditions

In a dry place, at a temperature not exceeding 20 °C

Shelf life

3 years 6 months

Manufacturer

Biosynthesis, Russia