GOU-ON, 2.5 ml syringe

GO-ONR is a sterile, non-pyrogenic sodium hyaluronate solution in a ready-to-use syringe containing 2.5 ml of 1% sodium hyaluronate solution, which is obtained from Streptococus equi culture by fermentation and subsequent purification.

Indications

GO-ON® is used to improve the viscoelastic properties of the synovial fluid of the knee and shoulder joints. GO-ON® as a viscoelastic fluid is indicated for injection into other joints. This provides lubrication and cushioning to the joints. This drug is recommended for the relief of symptoms of osteoarthritis.

Pharmacological effect

Due to the hyaluronic acid it contains, synovial fluid has viscoelastic properties. It is present in all joints, especially in large ones, which bear a large functional load; thanks to it, lubrication and shock absorption are provided, which ensures normal painless movements. In addition, synovial fluid provides nutrition to the articular cartilage. Degenerative joint diseases, such as osteoarthritis, are accompanied by a significant loss of viscosity of the synovial fluid, the lubricating and shock-absorbing properties of which deteriorate. As a result, the mechanical impact on the joint increases, resulting in accelerated wear of the articular cartilage, which, in turn, leads to pain and loss of function of the affected joint. It was found that as a result of intra-articular administration of sodium hyaluronate solutions, the viscoelastic properties of synovial fluid improve. In addition, its lubricating and shock-absorbing functions improve, which reduces the mechanical impact on the joint. As a result, pain decreases and joint mobility improves. Improvements observed after a course of 5 injections can last up to 6 months.

Composition

A syringe with GO-ON® contains 2.5 ml of a 1% sodium hyaluronate solution. Excipients: sodium chloride, sodium hydrogen phosphate dehydrate, sodium hydrogen phosphate dodecahydrate and water for injection.

Pregnancy

Use for women during pregnancy and lactation: although the teratogenic effect of this drug has not been detected in animals,
The safety of its use in women has not been determined. Therefore, the drug is recommended to be prescribed with caution to pregnant women
planning pregnancy. It has been found that sodium hyaluronate is excreted in milk in animals, so breastfeeding is not recommended during treatment.

Contraindications

The use of GO-ON® is contraindicated in patients with hypersensitivity to one of its components, as well as in patients with inflammatory diseases such as rheumatoid arthritis or ankylosing spondylitis.

Side Effects

Some patients may experience skin rash, hives and itching. In this case, the drug should be discontinued and appropriate treatment prescribed.
Manifestations such as pain (mainly transient pain after drug administration), swelling, joint effusion, and infection were observed rarely. Patients may sometimes complain of redness, a feeling of heat and heaviness at the injection site.
Shock phenomena were observed rarely. There is a possibility of anaphylactic reactions. Stop administration at the first sign of shock
drug, carefully monitor the patient’s condition and prescribe adequate treatment.
The administration of GO-ON® may be accompanied by local side effects, such as pain, a feeling of heat, redness and/or swelling, and joint effusion. Infection. This adverse effect can be relieved by applying an ice pack to the affected joint for 5-10 minutes.

Interaction

There is a known incompatibility between sodium hyaluronate and quaternary ammonium salts such as benzalkonium chloride, which may
used for skin disinfection. Therefore, GO-ON® should never come into contact with these substances, nor should medical or surgical instruments be treated with these substances, since in their presence hyaluronic acid may precipitate.
There is no data on the incompatibility of GO-ON® with other solutions for intra-articular administration. In the first days of treatment with GO-ON®, the patient can be prescribed analgesics and anti-inflammatory drugs.

Clinical pharmacology

Sodium hyaluronate is a natural high-molecular polysaccharide consisting of unbranched chains of disaccharides formed by sodium glucuronate and N-acetylglucosamine. Sodium hyaluronate penetrates well into the tissues of the human body. It is found in high concentrations in synovial fluid, of which it is the main component. Serving as a tissue lubricant, sodium hyaluronate plays an important role in regulating the physical and mechanical interaction between adjacent tissues, in addition, it acts as a viscoelastic element that prevents tissue adhesion.
Different forms of sodium hyaluronate have different molecular weights but the same chemical structure.
GO-ON® is a 1% solution of sodium hyaluronate, which is obtained from the culture of Streptococcus Equi through fermentation and subsequent purification.

Specifications

Sodium hyaluronate is a natural high-molecular polysaccharide consisting of unbranched chains of disaccharides formed by sodium glucuronate and N-acetylglucosamine. Sodium hyaluronate penetrates well into the tissues of the human body. It is found in high concentrations in synovial fluid, of which it is the main component. Serving as a tissue lubricant, sodium hyaluronate plays an important role in regulating the physical and mechanical interaction between adjacent tissues, in addition, it acts as a viscoelastic element that prevents tissue adhesion.
Different forms of sodium hyaluronate have different molecular weights but the same chemical structure.
GO-ON® is a 1% solution of sodium hyaluronate, which is obtained from the culture of Streptococcus Equi through fermentation and subsequent purification.

Storage conditions

Store at room temperature no higher than 25 °C.

Shelf life

3 years.

Manufacturer

Biologici Italia Laboratories S.r.L., Italy