Gonadotropin chorionic, lyophilisate 1500 units 5 pcs

• The drug has gonadotropic effect, mainly luteinizing;

• Stimulates the synthesis of sex hormones in the ovaries and testicles;

• Stimulates ovulation in women and spermatogenesis in men;

• Stimulates the development of the genitals and secondary sexual characteristics.

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Indications

Hypofunction of the gonads in men and women, caused by disruption of the activity of the hypothalamus and pituitary gland.

In women: anovulatory infertility, corpus luteum insufficiency (in the presence of estrogenic ovarian function), induction of superovulation during assisted reproductive techniques, recurrent miscarriage, threatened spontaneous miscarriage.

In men: hypogenitalism, eunuchoidism; testicular hypoplasia, cryptorchidism; adiposogenital syndrome, pituitary dwarfism, sexual infantilism; oligoasthenospermia, azoospermia.

For the purpose of differential diagnosis of cryptorchidism and anarchism in boys and for the purpose of assessing testicular function in hypogonadotropic hypogonadism.

Pharmacological effect

The drug has a gonadotropic effect, predominantly luteinizing;

Stimulates the synthesis of sex hormones in the ovaries and testicles;

Stimulates ovulation in women and spermatogenesis in men;

Enhances the development of genital organs and secondary sexual characteristics.

Special instructions

In men, the drug is ineffective with high levels of follicle-stimulating hormone (FSH).

With prolonged treatment or use in large doses in male adolescents with disorders of physical and sexual development, premature puberty is possible.

Unreasonably long-term use of the drug for cryptorchidism, especially if surgery is indicated, can lead to degeneration of the gonads.

Inhibition of FSH production due to stimulation of the production of androgens and estrogens contributes to atrophy of the seminiferous tubules.
Long-term administration may lead to the formation of antibodies to the drug.
Increases the likelihood of multiple pregnancies.

Erroneous results are possible when using a pregnancy test during treatment with the drug and for 7 days after its discontinuation.

Active ingredient

Chorionic gonadotropin

Composition

Active substance

human chorionic gonadotropin 5000 units;

Excipients

mannitol (mannitol).

5 bottles of the drug in a blister pack and 5 ampoules of 1 ml of sodium chloride solution for injection 0.9% in a blister pack, along with instructions for use of the drug and solvent, are placed in a cardboard box.

Contraindications

Hypersensitivity to the components of the drug, pituitary tumor, hormonally active tumors of the gonads (including androgen-dependent), absence of the gonads (congenital or after surgery), early menopause, thrombophlebitis, lactation, ovarian cancer, hypothyroidism, adrenal insufficiency, hyperprolactinemia, obstruction of the fallopian tubes.

With caution: adolescence, coronary heart disease, arterial hypertension, chronic renal failure, bronchial asthma, migraine.

Side Effects

Local reactions (pain at the injection site, hyperemia);

Allergic reactions;

Headache;

Increased fatigue;

Irritability;

Anxiety;

Depression;

Suppression of the gonadotropic function of the pituitary gland.

In women with combined treatment of infertility (in combination with menotropins and clomiphene) – ovarian hyperstimulation syndrome.

In men: fluid retention, swelling, increased sensitivity of the nipples of the mammary glands, gynecomastia, enlarged testicles in the inguinal canal (with cryptorchidism). As a result of long-term use of the drug in men, a decrease in the number of sperm in the ejaculate was found.

Interaction

Chorionic gonadotropin is used in combination with menopausal gonadotropin in the treatment of infertility.

Overdose

In case of an overdose of the drug, women may experience ovarian hyperstimulation syndrome with an increase in their size due to ovarian cysts with the danger of their rupture, the appearance of ascites and hydrothorax.

Its appearance may be indicated by symptoms such as a feeling of tension and abdominal pain, vomiting, diarrhea, difficulty breathing, and weight gain.

Treatment is symptomatic.

Storage conditions

In a place protected from light, at a temperature not exceeding 20 °C

Shelf life

4 years

Manufacturer

Moscow Endocrine Plant, Russia