Glucofage Long, 1000 mg 30 pcs

Type 2 DiabetesDiabetes mellitus in adults, especially in obese patients, if diet therapy and exercise are ineffective:

• as monotherapy;

• in combination with other oral hypoglycemic agents or with insulin.

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Active ingredient

Composition

1 tablet contains

The active ingredient:

metformin hydrochloride – 1000.0 mg;

Associates:

Sodium carmellose – 50.0 mg,

Hypromellose 2208 – 392.3 mg,

Magnesium stearate – 7.0 mg.

How to take, the dosage

Interaction

Contraindicated combinations

Iodine-containing radiopaque agents: Against the background of functional renal insufficiency in patients with diabetes mellitus, radiological examination with iodine-containing radiopaque agents may cause development of lactocidosis. Glucophage® ® Long should be discontinued depending on renal function 48 hours before or at the time of radiologic investigation with iodine-based radiopaque agents and should not be resumed until 48 hours after, provided that renal function was considered normal at the time of investigation.

Do not recommend combinations

Alcohol: Acute alcohol intoxication increases the risk of lactoacidosis, especially in cases:

– undernutrition, adherence to a low-calorie diet;

– hepatic insufficiency.

Alcohol and medicinal products containing ethanol should be avoided while taking the drug.

Combinations requiring caution

Drugs with indirect hyperglycemic effects (e.g., glucocorticosteroids (GCS) and tetracosactide (systemic and topical), beta2-adrenomimetics, danazol, chlorpromazine when taken at high doses (100 mg daily) and diuretics): More frequent monitoring of blood glucose concentrations may be required, especially at the beginning of treatment. If necessary, the dose of Glucophage® Long may be adjusted during treatment and after discontinuation of treatment, based on the level of glycemia.

Diuretics: concomitant use of “loop” diuretics may lead to the development of lactoacidosis due to possible functional renal failure.

The concomitant use of Glucophage® Long with sulfonylurea derivatives, insulin, acarbose, salicylates may lead to hypoglycemia.

Nifedipine increases absorption and Cmax metformin. Cationic drugs (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim and vancomycin) that are secreted in the renal tubules compete with metformin for tubular transport systems and may lead to an increase in its Cmax.

Contraindications

Side effects

Overdose

Pregnancy use

Similarities