Glencet, 5 mg 7 pcs.

Glencet is an enantiomer of cetirizine:

– a competitive histamine antagonist;

– blocks H1 -histamine receptors, the affinity for which is 2 times higher than that of cetirizine;

– has an effect on the histamine-dependent stage of allergic reactions;

– reduces migration of eosinophils, vascular permeability;

– limits the release of inflammatory mediators;

– prevents and eases the development of allergic reactions;

– has anti-exudative, antipruritic action;

– practically has no anticholinergic and antiserotonin action;

– in therapeutic doses, the sedative effect is very mild.

The action begins 12 minutes after a single dose in 50% of patients, after 1 hour in 95% of patients and lasts for 24 hours.

Indications

Symptomatic treatment of year-round and seasonal allergic rhinitis and allergic conjunctivitis (sneezing, rhinorrhea, lacrimation, conjunctival hyperemia), pollinosis, urticaria (incl.including chronic idiopathic, Quincke’s edema) and other allergic dermatoses accompanied by itching and rashes.

Active ingredient

Composition

Active ingredient:

levocetirizine dihydrochloride 5 mg

Associates:

Lactose monohydrate (Tabletose 100)

Microcrystalline cellulose (Avicel PH 112)

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colloidal silicon dioxide (Aerosil 200)

magnesium stearate

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How to take, the dosage

Overly, with meals or on an empty stomach, with a small amount of water, without chewing.

The recommended dosage for adults and children over 6 years of age, and for elderly patients (if renal function is normal) is 5 mg (1 tablet) once daily.

In patients with chronic renal failure, the dose is reduced 2-fold (1 tablet every other day) in patients with a CK of 30 to 49 ml/min and 3-fold (1 tablet every 3 days) in patients with a CK of 10 to 29 ml/min.

Patients with hepatic impairment do not require dosing adjustments.

The course of treatment in chronic diseases is up to 18 months.

Interaction

Theophylline (400 mg/day) decreases total clearance of levocetirizine by 16%, while the kinetics of theophylline is not changed.

The co-administration with macrolides or ketoconazole did not cause significant changes in ECG.

It may increase the effect of CNS depressants and ethanol.

Special Instructions

Caution is required for concomitant use with alcohol (see Interaction with other medicinal products).

Impact on the ability to drive and operate machinery

An objective assessment has not reliably observed any effect of the drug on the ability to drive and operate machinery when taken in the recommended dose.

Nevertheless, during the period of taking the drug it is advisable to refrain from potentially hazardous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity, including to piperazine derivatives,

serious chronic renal failure (creatinine Cl

Side effects

Headache, drowsiness, dry mouth, fatigue; rarely – migraine, dizziness, dyspeptic symptoms, allergic reactions (angioedema, rash, urticaria, itching).

Overdose

Symptoms: drowsiness, in children – anxiety, irritability.

Treatment: gastric lavage, activated charcoal, symptomatic therapy.

There is no specific antidote.

Hemodialysis is ineffective.

Pregnancy use

The drug is contraindicated in pregnancy and lactation.

Similarities