Gentamicin, 4%, 2 ml, 10 pcs.

A broad-spectrum antibiotic of the aminoglycoside group. < br>

It binds to 30S subunit of ribosomes and disrupts protein synthesis, preventing formation of transport and information RNA complex, thus causing misreading of genetic code and formation of non-functional proteins.

The drug has bactericidal action against many Gram-positive and Gram-negative microorganisms, including Pseudomonas aeruginosa, Escherichia coli, Enterobacter spp, Proteus spp., Klebsiella spp., Serratia spp., Citrobacter spp., Providencia spp., Campylobacter pylori, Campylobacter jejuni, Salmonella spp., Shigella spp., Francisella tularensis, Acinetobacter calcoaceticus, Aeromonas spp.

It acts on strains of Staphylococcus spp. resistant to penicillin.

Resistance of microorganisms develops slowly, but strains resistant to neomycin and kanamycin are also resistant to gentamicin (cross-resistance).

The drug has no effect on anaerobes, fungi, viruses, protozoa.

Indications

Infectious inflammatory diseases caused by susceptible Gram-negative aerobic bacteria:

Active ingredient

Composition

Active substance:

Gentamicin sulfate 40 mg in 1 ml of solution (80 mg in ampoule)

Directions for use

The drug is administered intramuscularly and intravenously.

A typical daily dose in adults with diseases of moderate severity is Zmg/kg, the frequency of administration is 2 to 3 times a day. In severe disease the daily dose is 5 mg/kg, the number of times the drug is administered 3-4 times a day; after the condition improves, the dose is reduced to 3 mg/kg/day. Maximum daily dose is 5 mg/kg.

In patients with urinary tract infections and normal renal function, a single dose of 120-160 mg daily for 7-10 days; in gonorrhea 240-280 mg once daily. When a single intravenous daily dose of gentamicin is administered intravenously, the time of administration should be 30-60 minutes. In case of 2 or 3 times administration of gentamicin: its concentration in the serum before the next administration should not exceed 2 µg/ml, in case of single administration – not more than 1 µg/ml. The average duration of treatment is 7-10 days.

In children from 1 month to 12 years of age the drug is administered intramuscularly or intravenously at a dose of 6 mg/kg/day in 1-3 doses.

Children over 12 years of age: intramuscularly or intravenously 2-5 mg/kg/day in 1-3 doses.

Prevention of postoperative abdominal infections: a single dose of gentamicin in combination with metronidazole or clindamycin is prescribed for intestinal surgery.

Special Instructions

The probability of nephrotoxicity is higher in patients with impaired renal function as well as when high doses of the drug are prescribed for a long time, therefore renal function should be monitored regularly (1 or 2 times a week), and in patients who have been treated for more than 10 days – daily.

In order to avoid development of hearing impairment it is recommended to conduct regular (1 or 2 times a week) vestibular function and hearing tests, monitor renal function as well as to determine gentamicin concentration in blood.

If symptoms of hearing loss are detected, the drug dose is reduced or treatment is discontinued.

With prolonged therapy resistance of microorganisms may develop, in which case the drug should be stopped.

Contraindications

Side effects

Oliguria, proteinuria, microhematuria, renal failure, hearing loss, deafness, vestibular disorders, increased liver transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia; nausea, vomiting, headache, somnolence, neuromuscular conduction disorders, allergic reactions (skin rash, itching, fever, rarely – Quincke’s edema).

Similarities