Gastal, tablets 60 pcs.

Pharmacotherapeutic group: antacid Drug ATX code: A02AD01 Pharmacological properties Pharmacodynamics Gastal® is a combined antacid drug that reduces increased acidity of gastric juice and has no stimulating effect on gastric juice secretion. Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after intake) and long-term (about 2 hours) neutralization of gastric hydrochloric acid, and maintenance of gastric acidity at physiological level (pH 3-5). One tablet of Gastal® neutralizes 21.5 mmol of hydrochloric acid. Gastal® inhibits the action of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Strengthens protective and regenerative processes in gastric mucosa. Aluminum ions have cytoprotective effect due to increased secretion of mucin and sodium hydrocarbonate, activation of prostaglandin E2 and NO, accumulation of epidermal growth factor in place of mucous membrane injury, increased concentration of phospholipids in gastric walls. Pharmacokinetics Gastal® has no systemic effect in patients with normal renal function. After interaction with hydrochloric acid of gastric juice aluminum hydroxide reacts with phosphates and carbonates in alkaline intestinal environment and is excreted with feces as insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect, which neutralizes the fixing effect of aluminum hydroxide in the small intestine. Magnesium ions are excreted with feces in the form of insoluble carbonate.

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