Gastal, mint tablets 12 pcs.

Sour belching, Peptic ulcer, Heartburn, Gastritis, Reflux esophagitis, Chronic pancreatitis – dyspeptic phenomena such as: discomfort or pain in the stomach, heartburn, sour belching after errors in diet, excessive consumption of alcohol, coffee, nicotine, etc.
– dyspeptic phenomena, such as: discomfort or pain in the stomach, heartburn, belching (and their prevention), arising from the use of certain medications (non-steroidal anti-inflammatory drugs, glucocorticosteroids and others).
– conditions accompanied by increased acid generation: gastric ulcer, gastritis, inflammation of the mucous membrane of the esophagus, resulting from regular discharge of gastric contents into the esophagus, hernia of the esophageal opening of the diaphragm.

If there is no improvement or you feel deterioration after 14 days, it is necessary to consult a doctor.

Indications

• dyspepsia, such as: discomfort or pain in the stomach, heartburn, sour belching after errors in the diet, excessive consumption of alcohol, coffee, nicotine, etc.;
• dyspepsia, such as: discomfort or pain in the stomach, heartburn, sour belching (and their prevention), resulting from the use of certain medications (non-steroidal anti-inflammatory drugs, glucocorticosteroids, etc.);
• conditions accompanied by increased acid formation: gastric ulcer, gastritis, inflammation of the mucous membrane of the esophagus, resulting from regular reflux of gastric contents into the esophagus, hiatal hernia.

If there is no improvement or you feel worse after 14 days, you should consult a doctor.

Pharmacological effect

Pharmacotherapeutic group: antacid

ATX code: A02AD01

Pharmacological properties

Pharmacodynamics

The drug Gastal® is a combined antacid that reduces the increased acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice.

Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after administration) and long-term (about 2 hours) neutralization of hydrochloric acid in gastric juice, maintaining acidity in the stomach at a physiological level (pH 3-5). One tablet of Gastal® neutralizes 21.5 mmol of hydrochloric acid.

The drug Gastal® suppresses the effect of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Strengthens protective and regenerative processes in the gastric mucosa. Aluminum ions have a cytoprotective effect by increasing the secretion of mucin and sodium bicarbonate, activating prostaglandin E2 and NO, accumulating epidermal growth factor at the site of mucosal damage, and increasing the concentration of phospholipids in the walls of the stomach.

Pharmacokinetics

The drug Gastal® does not have a systemic effect in patients with normal renal function. After interacting with the hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and is excreted in the feces in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect that neutralizes the fixing effect of aluminum hydroxide in the small intestine. Magnesium ions are excreted in the feces in the form of insoluble carbonate.

Special instructions

Before taking Gastal®, consult your doctor or pharmacist.

The recommended dose and duration of treatment should not be exceeded when used in patients with impaired renal function.

In young children, use of magnesium hydroxide may cause elevated magnesium levels in the body, especially if they have severe kidney disease or dehydration.

Children and teenagers

The drug Gastal® is not intended for use in children under 6 years of age.

Driving vehicles and working with machinery

The use of the drug Gastal® does not affect the ability to drive vehicles or control other mechanisms.

The drug Gastal® contains lactose monohydrate

If you have an intolerance to certain sugars, contact your doctor before taking this medicine.

Active ingredient

Aluminum hydroxide-magnesium carbonate, magnesium hydroxide

Composition

The active ingredients are: aluminum hydroxide-magnesium carbonate and magnesium hydroxide.

Gastal, lozenges [mint]

Each tablet contains 450.00 mg aluminum hydroxide-magnesium carbonate gel and 300.00 mg magnesium hydroxide.

Other ingredients (excipients) are: lactose monohydrate, mannitol, pregelatinized starch, colloidal silicon dioxide, croscarmellose sodium (type A), aspartame, magnesium stearate, mint flavor.

Gastal, lozenges [cherry]

Each tablet contains 450.00 mg aluminum hydroxide-magnesium carbonate gel and 300.00 mg magnesium hydroxide.

Other ingredients (excipients) are: lactose monohydrate, mannitol, pregelatinized starch, colloidal silicon dioxide, croscarmellose sodium (type A), aspartame, magnesium stearate, cherry flavor E 9407963 (cherry tablets).

Gastal, lozenges [orange]

Each tablet contains 450.00 mg aluminum hydroxide-magnesium carbonate gel and 300.00 mg magnesium hydroxide.

Other ingredients (excipients) are: lactose monohydrate, mannitol, pregelatinized starch, colloidal silicon dioxide, croscarmellose sodium (type A), aspartame, magnesium stearate, orange flavor 1013042 (orange tablets).

Pregnancy

If you are pregnant or breastfeeding, think you may be pregnant, or are planning a pregnancy, consult your doctor or pharmacist before using this medicine.

Pregnancy
When used during pregnancy and breastfeeding, it is necessary to evaluate the balance of benefit to the mother and risk to the fetus and infant. The drug should be used during pregnancy only if necessary and only on the advice of a doctor.

Breastfeeding
The drug Gastal® is not excreted in breast milk.

Contraindications

– allergy to aluminum salts, magnesium salts or any other components of the drug (listed in section 6 of the package insert);
– severe renal impairment, which is usually manifested by a significant increase in creatinine levels in the blood and is called severe renal failure;
– Alzheimer’s disease;
– reduced concentration of phosphates in the blood;
– lactose intolerance, deficiency of the lactase enzyme in the intestinal mucosa, glucose-galactose malabsorption (a rare genetically determined malabsorption of the sugars glucose and galactose in the intestine);
– children’s age up to 6 years.

Side Effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

You should stop taking the drug in case of nausea, diarrhea, constipation, increased levels of magnesium in the body, or seek immediate medical help in case of allergic reactions and abdominal pain.

Summary of Adverse Reactions

Rarely (no more than 1 person in 1,000) – nausea, diarrhea, constipation.

Very rare (may occur in no more than 1 person in 10,000) – allergic reactions, increased levels of magnesium in the body (observed after long-term use of magnesium hydroxide in patients with renal failure).

Frequency unknown (based on the available data, the frequency of occurrence cannot be determined) – pain in the abdomen.

Interaction

Tell your doctor or pharmacist if you are taking, have recently taken, or may start taking any other medications.

The drug Gastal®, when used simultaneously, enhances the activity of levodopa and nalidixic acid, reduces and slows down the intestinal absorption of quinolones, isoniazid, naproxen, iron preparations, indomethacin, aminazine, beta-blockers, diflunisal, H2-histamine receptor blockers, fat-soluble vitamins, indirect anticoagulants, barbiturates.

When interacting with metal ions included in antacids, tetracyclines form insoluble chelate complexes; as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. The simultaneous use of these drugs is not possible. If concomitant use is necessary, tetracycline should be taken at least 2 hours before taking the antacid.

In the presence of aluminum and magnesium hydroxides contained in the antacid, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%.

In the presence of antacids, the penetration of captopril into the blood is significantly reduced, and the simultaneous use of antacids and metoprolol leads to a decrease in the concentration of metoprolol in the blood plasma.

Concomitant use of high doses of antacids can reduce the absorption of ranitidine by 10-33%.

The use of antacids does not affect the proportion of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid that enters the bloodstream after taking these drugs, but may significantly reduce the absorption of doxycycline from the gastrointestinal tract.

An increase in urine pH during antacid therapy may increase the tubular reabsorption of basic (alkaline) drugs and reduce the reabsorption of acidic compounds. Antacids can reduce and slow down the absorption of salicylates in the intestine, including acetylsalicylic acid, and also, by increasing the pH of urine, promote more rapid excretion of salicylates in the urine from the body, with a concomitant decrease in their concentration in the blood serum by 30-70%.

The absorption of cardiac glycosides, including digoxin and digitoxin, is not significantly reduced when used simultaneously with antacids.

M-anticholinergic blockers, by slowing down gastric motility, increase the duration of action of the drug Gastal®.

In order to prevent possible interaction of the drug Gastal® with other drugs, it is recommended to take it 1 hour before or 1 hour after their use.

Overdose

Symptoms of acute overdose are not described.

Storage conditions

Keep the drug out of the reach of children and so that the child cannot see it.

Store at a temperature not exceeding 25 ºС.

Do not throw the drug into the sewer. Ask your pharmacist how to dispose of (destroy) a drug that is no longer needed. These measures will protect the environment.

Shelf life

Do not use the drug after the expiration date (shelf life) indicated on the carton after “Best Before”.
The expiration date is the last day of the given month.

Manufacturer

Pliva Hrvatska d.o.o., Croatia