Gairo, 500 mg 10 pcs

Pharmacodynamics

Active against trichomonads, giardia, dysentery amoeba, some anaerobic microorganisms (bacteroides, fusobacteria, some strains of clostridia, anaerobic cocci).

Pharmacokinetics

Gastrointestinal absorption is high. Bioavailability – 90%. Tmax – 1-2 hours. Binding to plasma proteins – at least 15%. It penetrates through the BBB. T1/2 is about 13 hours. It is excreted as metabolites by kidneys (60-70%) and with feces (20-25%), about 5% of dose is excreted unchanged.

Indications

Trichomoniasis, amebiasis, giardiasis, prevention of infections caused by anaerobic bacteria, in operations on the colon and in gynecology.

Active ingredient

Composition

Tablets, film-coated 1 tab.

ornidazole500 mg

auxiliary substances:

MCC;

Lactose;

Aerosil-200;

povidone (K-30);

magnesium stearate;

purified talc;

purified water;

sodium lauryl sulfate;

croscarmellose sodium

coating:

Hypromellose (HPMC E-15); polyethylene glycol 400; purified talc; quinoline yellow; brilliant green; titanium dioxide; isopropyl alcohol; dichloromethane; polyethylene glycol 6000; distilled water

How to take, the dosage

In trichomoniasis. Adults, acute form – 1.5 g once or in several doses during the day, chronic form – 500 mg 2 times a day (morning and evening) for 5 days. In children – once at a rate of 25 mg/kg.

In nonspecific vaginitis – 500 mg 2 times a day for 7 days; in children – 25 mg/kg/day, for 5-10 days.

In amebic dysentery. Adults and children with body weight over 35 kg – 1.5 g once daily; children with body weight less than 35 kg – 40 mg/kg/day for 3 days.

In other forms of amebiasis. Adults and children over 12 years of age – 500 mg 2 times a day (morning and evening), for 5-10 days. For children 7-12 years old – 375 mg; from 1 to 6 years old – 250 mg; up to 1 year old – 125 mg 2 times a day (morning and evening), for 5-10 days.

In giardiasis. Adults and children with body weight over 35 kg – 1.5 g once a day, children with body weight less than 35 kg – 40 mg/kg/day for 1-2 days.

For prophylaxis of infections caused by anaerobic bacteria it is 0.5-1 g before surgery, after surgery – 500 mg 2 times a day for 3-5 days.

Interaction

Enhances the effect of coumarin anticoagulants, prolongs the myorelaxant effect of vecuronium bromide. It is compatible with alcohol (does not inhibit acetaldehyde dehydrogenase).

Special Instructions

When treating trichomoniasis, both partners should be treated simultaneously.

Contraindications

Hypersensitivity, CNS disorders, pregnancy (I trimester), breastfeeding.

Side effects

Headache, dizziness, impaired consciousness, tremor, muscle rigidity, discoordination of movements, seizures, sensory or mixed peripheral neuropathy, nausea, vomiting, diarrhea.

Overdose

Symptoms: epileptiform seizures, depression, peripheral neuritis.

Treatment: symptomatic therapy (diazepam for seizures).

Pregnancy use

It is contraindicated in the first trimester of pregnancy. Breastfeeding should be stopped during treatment.

Similarities