Furazolidon Reneval, tablets 50 mg 10 pcs

Pharmacotherapeutic group: antimicrobial and antiprotozoal agent – nitrofuran.

The ATX code: G01AX06

Pharmacological properties

Pharmacodynamics

An antimicrobial and antiprotozoal agent, a nitrofuran derivative. It is active against the following microorganisms: Trichomonas spp., Giardia lamblia, Shigella dusenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella typhi, Salmonella paratyphi, Staphylococcus spp. Weak effect on pathogens of purulent and anaerobic infection. Resistance of microorganisms develops slowly. It blocks monoamine oxidase.

Nitrofurans disrupt cell respiration of microorganisms, inhibit the tricarboxylic acid cycle (Krebs cycle) and also inhibit the biosynthesis of nucleic acids of microorganisms, resulting in destruction of their envelope or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms release fewer toxins, so that improvement of the patient’s general condition is possible even before a pronounced suppression of microflora growth. Unlike many other antimicrobial drugs they do not suppress, but even activate the body’s immune system (increase complement titers and the ability of leukocytes to phagocytize microorganisms).

Pharmacokinetics

Absorption

It is well absorbed when taken orally.

Distribution

In the background of cerebral membrane inflammation, concentrations equal to those in blood plasma are produced in the cerebrospinal fluid.

Metabolism

It is rapidly and intensively metabolized mainly in the liver with the formation of pharmacologically inactive metabolite (amino derivative).

Elimination

Extracted mainly by the kidneys (65%). It is partially excreted with bile, reaching high concentrations in the intestinal lumen, which allows to use it in intestinal infections.

In case of renal failure furazolidone cumulates in the blood due to delayed excretion.

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Indications

Active ingredient

Composition

How to take, the dosage

Ingestion, after meals, with plenty of fluid (100-200 ml).

In the treatment of paratyphoid, dysentery, acute bacterial and protozoal diarrhea:

The drug Furazolidone Reneval is not recommended for more than 10 days.

In the treatment of giardiasis:

In adults: the highest single dose is 200 mg, the daily dose is 800 mg.

If after treatment, there is no improvement, or if symptoms get worse or new symptoms develop, you should talk to your doctor.

Interaction

Furazolidone in combination with ethanol may lead to the development of sulfiram-like reactions, and in this regard, their simultaneous use is not recommended.

The simultaneous use of furazolidone with monoamine oxidase inhibitors, sympathomimetics, tricyclic antidepressants and food containing tyramine causes the risk of a sharp increase in blood pressure; therefore, their simultaneous use is not recommended.

Aminoglycosides and tetracyclines increase the antimicrobial activity of Furazolidone Reneval.

Furazolidone increases the suppression of hematopoiesis against chloramphenicol and ristomycin.

Drugs that alkalize the urine (antacids containing calcium and magnesium, carbohydrate inhibitors, citrates, sodium hydrocarbonate) reduce the effect, and acidifying drugs (ammonium chloride, calcium chloride, hydrochloric acid, ascorbic acid, methionine) –
increase the effect of the drug Furazolidone Reneval.

If you use the above or other medicines (including over-the-counter medications), please consult your doctor before using the drug.

Special Instructions

In elderly people, caution should be exercised because of possible changes in renal function (dose reduction may be necessary).

The risk of hepatotoxic effects increases with underlying liver disease.

Because of the risk of disulfiram-like reactions, ethanol is not recommended during therapy with furazolidone and for 4 days after discontinuation. It is not used for urinary tract infections.

Avoid consumption of foods containing tyramine (cheese, beer, wine, beans, smoked meats, strong coffee, cream, pickled herring) and other vasoconstrictors, as there is a risk of hypertensive crisis.

The risk of peripheral polyneuropathies increases with anemia, diabetes, electrolyte imbalances, and hypovitaminosis B. Administration of B vitamins is required for prevention.

It contains 10,00 mg of sucrose per tablet, which is 0,002-0,003 units of a single dose (2-3 tablets) and 0,012 units of a daily dose of the drug, which must be taken into account by patients with diabetes.

Impact on driving, operating machinery

Do not use while working for persons who drive vehicles and operate potentially dangerous machinery because of the possibility of reduced concentration.

Synopsis

Contraindications

High sensitivity to furazolidone, drug components, to the group of nitrofurans; terminal stage of chronic renal failure; lactose intolerance, lactase deficiency, glucose-galactose malabsorption; Sucrose/isomaltase deficiency, fructose intolerance; glucose-6-phosphate dehydrogenase deficiency; pregnancy, breastfeeding; children under 3 years of age.

With caution

Chronic renal failure, liver and nervous system disorders, advanced age.

In renal failure, furazolidone does not create therapeutic concentrations in the urine, cumulates and may have toxic effects.

Side effects

Blood and lymphatic system disorders: leukopenia, agranulocytosis, hemolysis in persons with glucose-6-phosphate dehydrogenase deficiency.

Immune system disorders:hypersensitivity reactions (including decreased blood pressure, urticaria, fever, arthralgia, crust-like rash), skin itching, rash, including patchy-papular.

Nervous system disorders:headache, dizziness, peripheral neuropathy.

Vascular disorders: orthostatic hypotension, decreased blood pressure.

Gastrointestinal tract disorders: abdominal pain, nausea, vomiting, diarrhea, anorexia, colitis, proctitis, anal itching, staphylococcal enteritis.

Liver and biliary tract disorders: disordered liver function, cholestasis.

Recreational and urinary tract disorders:disordered renal function.

General disorders and disorders at the site of administration: Hypoglycemia, dark yellow staining of urine, weakness, malaise, disulfiram-like reaction (“rush” of blood to the face, slight increase in temperature, shortness of breath, feeling of tightness in the chest).

In long-term use, neuritis.

If you have any side effects mentioned in the instructions, or if they get worse, or if you notice any other side effects not mentioned in the instructions, tell your doctor.

Overdose

Pregnancy use

Similarities