Furazolidon Avexima, tablets 50 mg 20 pcs

The drug belongs to the antimicrobial and antiprotozoal agents.

It has bacteriostatic action against microbes.

The mechanism of action is disruption of activity of some enzyme systems of bacteria.

Spectrum of action: gram-positive cocci (Streptococcus, Staphylococcus), gram-negative bacilli (Escherichia, Salmonella, Shigella, Proteus, Klebsiella, Enterobacter), protozoa (Lamblia). Among intestinal pathogens the most sensitive are dysentery, typhoid and paratyphoid pathogens. Resistance develops slowly.

Indications

– dysentery;

– paratyphoid fever;

— food poisoning;

– giardiasis.

Pharmacological effect

The drug belongs to the class of antimicrobial and antiprotozoal agents.

Has a bacteriostatic effect against microbes.

The mechanism of action is to disrupt the activity of certain bacterial enzyme systems.

Spectrum of action: gram-positive cocci (Streptococcus, Staphylococcus), gram-negative bacilli (Escherichia, Salmonella, Shigella, Proteus, Klebsiella, Enterobacter), protozoa (Lamblia). Of the pathogens of intestinal infections, the most sensitive are the pathogens of dysentery, typhoid fever and paratyphoid fever. Resilience develops slowly.

Special instructions

Increases sensitivity to the action of ethanol.

Medicines that alkalize urine reduce the effect, while those that acidify urine increase it.

Aminoglycosides and tetracycline enhance antimicrobial properties.

During treatment, precautions must be observed, as when using monoamine oxidase inhibitors, namely: exclusion from the diet of foods containing tyramine: cheese, cream, beans, pickled herring, strong coffee.

To prevent neuritis with long-term use, it must be combined with B vitamins.

Active ingredient

Furazolidone

Composition

1 tablet contains

furazolidone 50 mg.

Active substance – furazolidone – 0.05 g,

excipients:

potato starch – 0.02 g,
calcium stearate (calcium stearate) – 0.001 g,
sugar (sucrose) – 0.01 g,
Tween-80 (polysorbate) – 0.0002 g,
lactose (milk sugar) – 0.0188 g

Pack of 20 pieces

Contraindications

— pregnancy and lactation;

— end-stage chronic renal failure;

– deficiency of glucose-6-dehydrogenase;

– children under 1 year of age;

– increased individual sensitivity to the group of nitrofurans.

Side Effects

In some cases, nausea, vomiting, loss of appetite, and allergic reactions (skin rash, hyperemia and itching of the skin, allergic edema) may occur.

With long-term use – neuritis.

Interaction

Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore their simultaneous use is not recommended.
Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephedrine, tyramine can cause a sharp increase in blood pressure.

Agents that alkalize urine reduce the effect (accelerate excretion in urine), while acidifying agents increase it. Aminoglycosides and tetracycline enhance antimicrobial properties.
Increases inhibition of hematopoiesis against the background of chloramphenicol and ristomycin.

Overdose

Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

Treatment: drug withdrawal, taking large amounts of fluid, symptomatic therapy, antihistamines, B vitamins.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding +25ºС, in places inaccessible to children.

Shelf life

3 years

Manufacturer

Avexima Siberia, Russia