Furagin, tablets 50 mg 30 pcs

Furagin is an antibacterial drug, a nitrofuran derivative. It acts bacteriostatically. The mechanism of action of Furagin is related to the effect on the enzymes involved in the transfer of hydrogen in the cells of sensitive microorganisms. High bacteriostatic activity of Furagin is due to the presence of aromatic nitro group.

The drug is active against Gram-positive bacteria: Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus faecalis; against Gram-negative bacteria: Enterobacteriaceae, Escherichia coli, Klebsiella pneumoniae.
Pseudomonas aeruginosa is resistant to the drug.

The minimum bacteriostatic concentration of Furagin (1 µg/ml) is 10-20 times lower than that of other nitrofuran derivatives. Furagin has the most pronounced effect in acidic environment (pH 5.5), alkaline environment prevents the action of the drug.

Indications

– treatment of acute and chronic infectious and inflammatory diseases of the urinary tract and prostate;
– prevention of recurrent urinary tract infections (including in children with congenital defects of the urinary system, in adults with prolonged catheterization).

Active ingredient

Composition

1 tablet contains:

the active ingredient:

furazidine 50 mg.

How to take, the dosage

For treatment of adults, 100 mg (2 tablets) 4 times a day is prescribed on the first day of therapy, on subsequent days – 100 mg 3 times a day.

In children the drug is prescribed in a daily dose of 5-7 mg/kg of body weight; in long-term treatment the daily dose is 1-2 mg/kg.
The course of treatment is 7-8 days. If necessary the course of treatment may be repeated after 10-15 days.

Interaction

In concomitant use of Furagin and nalidixic acid there is a decrease in the bacteriostatic effect of Furagin.

Concomitant use of Furagin and uricosuric drugs (probenecid, sulfinpyrazone) decreases excretion of furazidine in the urine, which leads to a decrease in its therapeutic effectiveness. This may lead to cumulation of furazidine in the body and increase the toxicity of Furagin.

Concomitant use of Furagin and antacids containing magnesium trisilicate decreases absorption of Furagin.

Special Instructions

Caution should be exercised when prescribing Furagin to diabetic patients as symptoms of polyneuropathy may occur during the use of the drug.
It is not recommended to prescribe Furagin in urosepsis as well as in infections of the kidney parenchyma.

When using Furagin, false positive results of urine glucose determination using Benedict and Fehling solutions may be observed. Results of urine glucose determination performed by enzymatic methods remain correct.

Control of laboratory parameters
During long-term treatment with Furagin, the leukocyte count in blood as well as liver and kidney function parameters should be periodically monitored.

Impact on driving and operating machinery

Furagin does not affect the speed of psychomotor reactions, therefore it can be administered to patients whose activities require increased attention.

Contraindications

– renal insufficiency;
– polyneuropathy (including. Diabetic);
– Insufficiency of glucose-6-phosphate dehydrogenase;
– Pregnancy: between 38 and 42 weeks;
– Lactation;
– Hypersensitivity to nitrofuran derivatives.
The drug is not prescribed to newborns before the end of the first month of life.

Side effects

Digestive system disorders: diarrhea, dyspeptic phenomena, abdominal pain, constipation, vomiting.

CNS and peripheral nervous system disorders: dizziness, drowsiness, visual impairment; rarely – polyneuropathy.

Allergic reactions: rash, itching.

Others: elevated body temperature, chills, malaise; rarely – pulmonary reactions caused by hypersensitivity to nitrofuran derivatives.

Overdose

Symptoms: headache, dizziness, depression, psychosis, peripheral polyneuritis, allergic reactions (urticaria, angioedema, bronchospasm), nausea, vomiting, megaloblastic or hemolytic anemia (in persons with glucose-6-phosphate dehydrogenase deficiency); very rarely – liver dysfunction.

The treatment: gastric lavage, intravenous infusion of infusion solutions; hemodialysis is indicated in severe cases.

Similarities