Fungoterbin Neo, gel 15 g

Terbinafine, the active ingredient of Fungoterbine®, is an allylamine and has a broad spectrum of antifungal action.

It is active against such dermatophytes as Trichophyton (T. rubrum, T. mentagrophytes, T. tonsurans, T. verrucosum, T. violaceum), Microsporum canis, Epidermophyton floccosum. In low concentrations it has

fungicidal action against dermatophytes, mold fungi (Aspergillus, Cladosporium, Scopulariopsis brevicaulis, etc.) and some dimorphic fungi.

The action on yeast fungi of the genus Candida and its mycelial forms may be fungicidal or fungistatic, depending on the type of fungus.

Terbinafine is also active against Pityrosporum – the causative agent of Pityriasis versicolor, caused by Pityrosporum ovale.

Terbinafine disrupts ergosterol biosynthesis in fungi at early stages. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes cell death of the fungus.

The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase located on the cell membrane of the fungus.

This enzyme is not part of the cytochrome P450 system. Terbinafine has no effect on the metabolism of hormones or other drugs.

The presence of urea in the cream and spray has a moisturizing effect and promotes deeper penetration of terbinafine into the skin, thus creating high concentrations.

In additionally for the spray: the urea (urea) contained in the spray has a keratolytic (softening and causing rejection of the stratum corneum of the epidermis affected by the fungal infection).

Carbamide promotes rapid regeneration of the epidermis. Butylhydroxytoluene is an antioxidant and stimulates regeneration processes. When used topically it inhibits free radical reactions.

Indications

Treatment and prevention of fungal skin diseases:

– fungal skin infections, including.including mycoses of the feet (“fungus” of the foot), inguinal epidermophytia (tinea cruris), fungal lesions of smooth skin of the body (tinea corporis), caused by dermatophytes such as Trichophyton (incl.T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum;

– skin infections caused by yeast-like fungi of the genus Candida (such as Candida albicans);

– variegated shingles (Pityrosporum versicolor) caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Active ingredient

Composition

1 g:

– terbinafine hydrochloride 10 mg

– urea 100 mg

Supplementary substances:

Butylhydroxytoluene (dibunol),

Carbomer (carbopol),

Trolamine (thermostable triethanolamine, 2,2I,2II-nitrile ethanol),

Propylene glycol, up to 1 g.

How to take, the dosage

Externally. Before application, the affected areas should be cleaned and dried. Fungoterbin® is applied 1 or 2 times a day to the affected areas of skin and adjacent areas.

The cream is applied in a thin layer and rubbed in gently. When applied to the skin folds (groin, interdigital area, under the breasts) it is recommended to use a gauze bandage/bandage.

Dermatomycosis of the trunk, large folds, shins: 1 time daily, duration of treatment – 1 week.

Dermatomycosis of the feet: 1 time per day, duration of treatment – 1 week.

Skin Candida: 1-2 times a day, duration of treatment 1-2 weeks;

Mottle capitis: 1-2 times a day, duration of treatment 1 week.

Contraindications

Hypersensitivity to terbinafine or any other component of Fungoterbin Neo.

Side effects

In rare cases, redness, itching or burning sensations have been observed where the cream was applied, but these phenomena have rarely made it necessary to discontinue treatment.

The above symptoms should be distinguished from allergic reactions (e.g., urticaria, generalized rash and/or redness, angioedema, repeated allergic reaction), which are rare, but should be discontinued if they occur.