Fungoterbin, cream 1% 15 g

Pharmacodynamics

Antifungal drug for topical use, it is an allylamine and has a wide spectrum of antifungal activity.

It is characterized by pronounced epidermotropism. The target for terbinafine is cytoplasmic membrane of fungal cell.

Terbinafine acts on the early stages of sterol metabolism, at the level of squalene epoxidase cycle.

Inhibiting the enzyme squaleneepoxidase, terbinafine inhibits formation of ergosterol – the main component of the cell wall of fungi, preventing their further reproduction.

Squaleneepoxidase is not associated with P450 system.

The fungicidal effect is due to accumulation of squalenes in the fungal cell which extract lipid components from membranes.

The lipid granules accumulated inside the cell gradually increase in volume and break the damaged cytoplasmic membranes leading to the death of the fungal cell.

Terbinafine is highly active against all dermatophytes belonging to Trichophyton, Microsporum and Epidermophyton genera.

Terbinafine in low concentrations has fungicidal effect against dermatophytes (Trichophyton rubrum, T.mentagrophytes, T.verrucosum, T.violaceum; Microsporum canis and Epidermophyton floccosum);

molds (Aspergillus spp, Scopulariopsis brevicaulis), yeasts – Candida albicans, C.stellatoidea, C.tropicalis, C.parapsilosis, C.guillermondi, C.kursei, C.pseudotropicalis, Pityrosporum orbiculare (P.ovale and Malassezia furfur); dimorphic fungi (Sporothrix schenckii and others).

The effect of terbinafine against yeast-like fungi, depending on their species, may be fungicidal (Candida parapsilosis) or fungistatic (Candida albicans).

Fungoterbin® also has anti-inflammatory, antipruritic and keratolytic effect. Due to the presence of urea in the cream, the drug has a moisturizing effect and promotes deeper penetration of terbinafine into the skin.

Pharmacokinetics

When applied topically the drug is only slightly absorbed (absorption – 5%); it is accumulated in skin, sebaceous glands, hair follicles, subcutaneous tissue and acts primarily in the application site.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Fungoterbin is generally well tolerated.

Side effects are usually mild to moderate and transient.

When taken orally there may be:

Gastrointestinal tract: dyspepsia, abdominal pain, feeling of stomach fullness, nausea, loss of appetite, diarrhea; sometimes impaired taste sensation, including loss of taste (recovered after several weeks of discontinuing treatment);

Musculoskeletal system: Muscle pain, joint pain

Hematopoietic system: neutropenia, agranulocytosis, thrombocytopenia, rarely – lymphopenia.

Allergic reactions: skin rash in the form of spots, blisters, rarely – toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylactoid reactions.

Overdose

Pregnancy use

The experience of using the drug in pregnancy is limited, therefore Fungoterbin should not be used in pregnancy.

Terbinafine is excreted with the breast milk, so if it is necessary to prescribe the drug, it is necessary to consider stopping breastfeeding.

Similarities