Fortum, 1 g

Fortum has a broad spectrum antibacterial action, bactericidal.

Indications

Severe infections, including hospital-acquired infections (septicemia, bacteremia, peritonitis, meningitis, infections in immunocompromised patients, infected burns); respiratory tract infections and infections in cystic fibrosis patients; infections of ENT organs; urinary tract infections; skin and soft tissue infections; infections of the GI tract, biliary tract and abdomen; infections of bones and joints; infections associated with dialysis; prevention of infectious complications during operations on the prostate (transurethral resection).

Active ingredient

Composition

1 bottle contains ceftazidime (in the form of pentahydrate) 1 g.

Excipients:

Sodium carbonate (anhydrous),

Carbon dioxide

How to take, the dosage

Iv or IM deeply into the upper outer quadrant of the greater gluteal muscle or the lateral thigh. Ceftazidime solution can be injected directly into a vein or into a tube of an infusion system.

The dose of the drug is determined individually depending on the severity of the disease, localization, type of the causative agent and its sensitivity to the drug as well as the patient’s age and renal function.

The maximum daily dose is 6 g.

Special Instructions

In case of allergic reaction to ceftazidime the drug should be withdrawn immediately, in severe cases adrenaline, hydrocortisone, antihistamines and other emergency measures may be required. When concomitant administration of cephalosporins in high dose with nephrotoxic drugs such as aminoglycosides and diuretics (furosemide), renal function should be monitored. Since ceftazidime is excreted through the kidneys, in patients with renal impairment its dose should be reduced according to the degree of renal impairment.

Long-term use of broad-spectrum antibiotics, including ceftazidime, may lead to increased growth of insensitive microorganisms (e.g. Candida, Enterococci), which may require discontinuation of treatment or appropriate therapy. During treatment it is necessary to constantly assess the patient’s condition.

When treated with ceftazidime some initially sensitive strains of Enterobacter and Serratia may develop resistance; therefore antibiotic sensitivity testing should be performed periodically when treating infections caused by these microorganisms.

Ceftazidime has no effect on the results of glucose determination in urine by enzymatic methods, but may have a weak effect on the results of methods based on copper reduction (Benedict, Fehling, Clinitest). Ceftazidime does not affect the quantitative determination of creatinine by the alkaline-picrine method (Jaffe method).

Contraindications

Hypersensitivity to ceftazidime or any other component of Fortum and to other cephalosporin antibiotics, penicillins.

Side effects

Local reactions: phlebitis or thrombophlebitis when Fortum is injected intravenously; pain, burning, thickening at the injection site when injected intravenously.

Hypersensitivity reactions: patchy-papular rash, urticaria, fever, pruritus, angioedema, bronchospasm, decreased BP, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

Gastrointestinal disorders: diarrhea, nausea, vomiting, abdominal pain; oropharyngeal candidiasis, colitis. As with other cephalosporins, colitis may be caused by Clostridium difficile and appear as pseudomembranous colitis.

Urogenital system disorders: candidal vaginitis, impaired renal function.

Hepatobiliary system and pancreatic disorders: very rare – jaundice.

CNS disorders: headache, dizziness, paresthesias, taste disorders. In patients with renal failure more often than in other patients neurological disorders are noted, including tremor, myoclonia, convulsions, encephalopathy, coma.

Laboratory parameters: eosinophilia, false positive direct Coombs reaction, thrombocytosis, increased activity of liver enzymes – ALT, AST, LDH, gamma-glutamyl transpeptidase and ALP. Sometimes there is a transient increase in blood levels of urea, urea nitrogen and/or creatinine.

Hematopoietic organs: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, lymphocytosis, hemolytic anemia.

Pregnancy use

With caution.

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