Foradil, 12 mcg 60 pcs

Beta-adrenergic stimulating agent, with selectivity towards the beta2-adrenoreceptors of bronchial smooth muscle, has a bronchodilator effect.

Foradil is effective for the prevention and relief of bronchospasm caused by allergens, physical activity, histamine, methacholine (diagnostic test).

Foradil has tocolytic properties. The onset of action is 1-3 minutes after inhalation, the duration of bronchodilator effect is 12 hours.

Indications

Treatment and prevention of reversible airway obstruction – COPD, bronchial asthma.

Active ingredient

Composition

1 capsule contains formoterol fumarate 12 mcg.

How to take, the dosage

Foradil is used by inhalation.

Adults with bronchospastic syndrome – 12-24 mcg 2 times a day, children from 5 years and older – 12 mcg (no more) 2 times a day; if necessary, you can use an additional 1-2 capsules.To prevent bronchospasm caused by exercise or exposure to a known allergen, inhale 1 dose (12 mcg) about 15 minutes before work or exposure to that factor; in severe cases of bronchial asthma, 2 doses (24 mcg) may need to be inhaled.

Interaction

Foradyl (as well as other beta2-adrenergic stimulants) should be used with caution in patients receiving drugs such as quinidine, disopyramide, procainamide, phenothiazines, antihistamines, MAO inhibitors, tricyclic antidepressants, and other drugs known to prolong QT interval, as their effect on the cardiovascular system may be increased.because in these cases, the effect of adrenostimulants on the cardiovascular system may increase. The use of medications that can prolong the QT interval increases the risk of ventricular arrhythmias.

The concomitant use of other sympathomimetic drugs may aggravate the side effects of Foradil.

The concomitant use of xanthine derivatives, GCS, or diuretics may increase the potential hypokalemic effects of beta2-adrenomimetics. Hypokalemia may increase the predisposition to develop cardiac arrhythmias in patients receiving foxglove drugs.

Beta-adrenoblockers may weaken the effects of Foradil. Therefore, Foradil should not be used in conjunction with beta-adrenoblockers (including eye drops) unless compelled to use such a combination of drugs for any extraordinary reason.

Special Instructions

Particular caution in the use of Foradil (especially in terms of dose reduction) and close monitoring of patients is required in the presence of the following comorbidities: CHD; cardiac rhythm and conduction disorders, especially grade III AV blockade; severe heart failure; idiopathic subclavian aortic stenosis; hypertrophic obstructive cardiomyopathy; thyrotoxicosis; known or suspected QTc interval prolongation (QT adjusted) >044 sec.

Because of the hyperglycemic effects inherent to beta2-adrenomimetics, additional regular monitoring of blood glucose levels is recommended in diabetic patients.

In general, patients with bronchial asthma who require therapy with beta2-adrenomimetics should also receive regular adequate doses of anti-inflammatory agents (e.g., GCS for inhaled or oral administration, and/or in children – sodium cromoglycate). When prescribing the drug in patients who are not receiving anti-inflammatory therapy, this should be started at the same time as the use of Foradil. When prescribing Foradil, patients should be evaluated regarding the adequacy of the anti-inflammatory therapy they are receiving. After starting treatment with Foradil, patients should be advised to continue anti-inflammatory therapy without change, even if improvement is noted.

The physician should review baseline asthma therapy if asthma symptoms persist with Foradil, or if the amount of Foradil dosing required to control symptoms increases, because this usually indicates a worsening of the disease course.

A consequence of therapy with beta2-adrenomimetics may be the development of potentially serious hypokalemia. Since this effect of the drug may be enhanced by hypoxia and concomitant treatment, special caution should be observed in patients with bronchial asthma of severe course. In these cases, regular monitoring of serum potassium levels is recommended.

As with other inhalation therapy, the possibility of paradoxical bronchospasm should be considered. If this occurs, the drug should be immediately withdrawn and an alternative treatment should be prescribed.

Contraindications

Hypersensitivity, children (under 5 years).

With caution.

Diabetes mellitus, severe CHD, CHD, cardiac rhythm disorders, AV blockade III, Q-T interval prolongation (Q-T corrected > 0.44 s), GOCMP, thyrotoxicosis, pregnancy, lactation period.

Side effects

Unwanted reactions are categorized according to the frequency of occurrence. The following criteria were used to assess the frequency: very common (≥10%); common (≥1%,

Allergic reactions: very rare – hypersensitivity reactions such as hypotension, urticaria, angioedema, pruritus, exanthema.

CNS disorders: often – headache, tremor; sometimes – agitation, anxiety, nervousness, insomnia, dizziness.

The cardiovascular system: often – palpitations; sometimes – tachycardia; very rarely – peripheral edema.

Respiratory system: sometimes – bronchospasm.

The digestive system: very rare – nausea; distortion of taste.

Muscular system: sometimes – muscle cramps, myalgia.

Local reactions: sometimes – irritation of the mucous membrane of the throat and larynx.

Overdose

Symptoms: Overdose of Foradil is suspected to cause phenomena characteristic of the excessive action of other beta2-adrenomimetics, such as nausea, vomiting, headache, tremor, somnolence, palpitations, tachycardia, ventricular arrhythmias, metabolic acidosis, hypokalemia, hyperglycemia.

Treatment: supportive and symptomatic therapy is indicated. In severe cases hospitalization is necessary.

The use of beta-adrenoblockers may be considered, but only with extreme caution and under close medical supervision, as the use of these agents may cause bronchospasm.

Pregnancy use

Foradil is contraindicated in pregnancy and lactation.