Fluconazole-Vertex, 150 mg capsules 4 pcs

Antifungal agent, has a highly specific action by inhibiting the activity of cytochrome P450-dependent fungal enzymes.

Blocks conversion of fungal cells lanosterol to ergosterol; increases cell membrane permeability, disrupts cell growth and replication. Fluconazole, being highly selective for cytochrome P450 of fungi, practically does not inhibit these enzymes in humans (in comparison with itraconazole, clotrimazole, econazole and ketoconazole it inhibits cytochrome P450 dependent oxidative processes in human liver microsomes to a lesser extent). It does not have antiandrogenic activity.

Active in opportunistic mycoses, including those caused by Candida spp. (including generalized candidiasis against immunosuppression), Cryptococcus neoformans and Coccidioides immitis (including meningitis and encephalitis), Microsporum spp. and Trichophyton spp; in endemic mycoses caused by Blastomyces dermatidis, Histoplasma capsulatum (including immunosuppression).

Indications

Active ingredient

Composition

Interaction

Directions for use

Special Instructions

Contraindications

– hepatic failure;

– renal failure;

– appearing rash on fluconazole in patients with superficial fungal infection and invasive/systemic fungal infections;

– concomitant use of terfenadine and fluconazole at a dose less than 400 mg/day;

Side effects

Overdose

Pregnancy use

Similarities