Flucoldex N, tablets, 12 pcs.

Flucoldex is a combination drug.

Caffeine has a moderate psychostimulant effect, temporarily reduces symptoms of fatigue and sleepiness. On the cardiovascular system due to a combination of central and peripheral effects on the heart and blood vessels it has mixed effects: coronary vessels tend to dilate, and brain vessels tend to tone up, BP slightly increases (more often with initial hypotension). Caffeine increases basal metabolism, has moderate myotropic antispasmodic effect (dilates bronchi, bile ducts), stimulates secretion of glands of the stomach, slightly increases diuresis.

The pharmacological properties of caffeine are conditioned by its competitive antagonism with adenosine at the level of A₁-adenosine receptor and by inhibition of phosphodiesterase activity.

Paracetamol has analgesic and antipyretic effects. These properties are caused by inhibition of PG synthesis in CNS – modulators of pain sensitivity and thermoregulation. It has practically no anti-inflammatory effect.

Chlorphenamine is a blocker of histamine H₁ receptors. In addition to antiallergic, it has some local anesthetic, antispasmodic, choline blocking, sedative and hypnotic effects. It is effective in kinetosis (motion sickness syndrome) and Meniere’s disease.

Indications

Active ingredient

Composition

Active ingredients:

Paracetamol 500 mg,

Caffeine 30 mg,

Chlorphenamine maleate 2 mg

How to take, the dosage

Tablets are taken orally, 1 tablet 2-3 times a day at intervals of at least 4 hours.

The maximum single dose for adults and children over 12 years is 2 tablets, the daily dose is 8 tablets.

The duration of use is not more than 5 days.

Lengthening the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Interaction

NSAIDs and CNS depressant drugs – possible increased side effects of the drug.

The risk of hepatotoxic effect is increased with concomitant administration of barbiturates, phenytoin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes, ethanol.

Reduces excretion and increases toxicity of chloramphenicol.

Metoclopramide and domperidone increase the rate of absorption of paracetamol, colestyramine slows it down.

The concomitant administration with indirect anticoagulants should be under constant medical supervision.

Special Instructions

The excessive consumption of tea, coffee and other products containing methylxanthines should be avoided.

In prolonged (more than 1 week) use of the drug it is necessary to monitor the peripheral blood picture and the functional state of the liver.

In case of hyperthermia lasting more than 3 days and pain syndrome lasting more than 5 days, it is necessary to consult a physician.
Paracetamol distorts laboratory values in the quantitative determination of plasma sugar and uric acid.
During the treatment it is necessary to refrain from the use of ethanol (possible development of hepatotoxic effect).

Impact on driving and operating machinery
During the treatment it is necessary to refrain from driving vehicles and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

With caution: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), alcoholism, closed-angle glaucoma, prostatic hyperplasia, pregnancy, lactation; older age, children (under 12 years).

Side effects

Overdose

Symptoms (caused by paracetamol): pallor of the skin, decreased appetite, nausea, vomiting; hepatonecrosis (severity of necrosis, due to intoxication, directly depends on the degree of overdose). Toxic effects in adults are possible after taking more than 10-15 g of paracetamol: increased liver transaminases activity, increased prothrombin time (12-48 hours after intake); the full clinical picture of liver damage is seen in 1-6 days. Rarely, liver failure develops fulminantly and may be complicated by renal failure (tubular necrosis).

Treatment: administration of SH-group donators and precursors of glutathione synthesis – methionine – 8-9 hours after overdose, and N-acetylcysteine – after 12 hours.

The need for additional therapeutic measures (further methionine administration, intravenous N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.