Flucinar N, ointment 15 g

Flucinard N is a combined drug with anti-inflammatory and antibacterial action.

Fluocinolone acetonide is a synthetic GCS for external use. It is 40 times more active than hydrocortisone. It has anti-inflammatory, antipruritic, antiexudative, anti-allergic and vasoconstrictor action. The mechanism of anti-inflammatory action is not fully elucidated. It is thought that fluocinolone acetonide decreases manifestations of the inflammatory process by inhibiting the synthesis of prostaglandins and leukotrienes through inhibition of phospholipase A2 activity and reducing the release of arachidonic acid from cell membrane phospholipids. As a result, hyperemia and exudation in the lesion are reduced. Stabilizes cellular and subcellular (including lysosomal) membranes. Reduces output of proteolytic enzymes from lysosomes. Reduces membrane permeability, mitotic activity and release of inflammatory mediators.

On skin exposure prevents marginal accumulation of neutrophils, which leads to a decrease in inflammatory exudate and lymphokine production, inhibition of macrophage migration, reduction of infiltration and granulation processes. Inhibits the alteration phase and limits the focus of inflammation, reduces the migration of leukocytes and lymphocytes to the focus of inflammation. Inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the severity of the early immune response.

Neomycin is an antibiotic of aminoglycoside group. In low concentrations it has bacteriostatic action, in high concentrations it is bactericidal. Mechanism of action is related to direct effect on ribosomes and inhibition of protein synthesis in bacterial cell.

Flucinar N is active against Gram-positive micro-negroms: Staphylococcus spp., Streptococcus spp., Corynebacterium diphtheriae, Listeria monocytogenes, Bacillus antracis, Clostridium spp., Actinomyces spp, Neisseria meningitidis; Gram-negative micro-organisms: Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter aerogenes, Vibrio cholerae, Haemophilus influenzae, Klebsiella pneumoniae, Bordetella pertussis, Pasteurella multocida, Borrelia spp., Treponema pallidum, Fusobacterium spp., Leptospira spp.

It has activity against acid-resistant Mycobacterium tuberculosis.

Microbial resistance to neomycin develops slowly and to a small extent.

As a result of the combined action of fluocinolone acetonide and neomycin, the drug suppresses the development of inflammatory-allergic skin reactions complicated by bacterial infection.

Indications

Allergodermatoses complicated by bacterial infection caused by neomycin-sensitive flora:

Active ingredient

Composition

Active ingredients:

Fluocinolone acetonide 0.25 mg,

neomycin sulfate 5 mg,

Her excipients:

propylene glycol;

liquid paraffin;

How to take, the dosage

Externally, a small amount of Flucinar N ointment is applied to the affected skin 2-3 times a day, not more than 2 g/day, after the acute inflammatory process calms down – 1-2 times a day. Breathable dressing is used if necessary. With excessive peeling of stratum corneum of epidermis (lichenization) or excessive keratinization of changed areas it is possible to use occlusive dressing, which is changed every 24-48 hours. The course of continuous treatment should not exceed 2 weeks.

Children over 2 years of age with caution, only once a day on small areas of skin.

Special Instructions

In case of long-term use and application to large areas of skin (under occlusive dressings) patients should be subjected to systematic examinations (systemic side effects are possible).

Contraindications

Side effects

Overdose

Symptoms: if the dosing regimen is not followed (prolonged use of the drug on large areas of skin) systemic side effects of the drug such as increased BP, edema, immunosuppressive effects are possible.

Treatment: discontinuation of the drug.