Flogenzyme, 200 pcs.

FLOGENSIM is a new generation drug consisting of a combination of highly active proteolytic enzymes (enzymes) of plant and animal origin – bromelain and trypsin combined with rutin.

In combination the enzymes have pleiotropic (multiple) effects with different pharmacological actions on pathophysiological and biochemical processes. Enzymes of the drug realize their therapeutic effects through anti-inflammatory, immunomodulatory, anti-aggregant, fibrinolytic, thrombolytic, antiedematous and secondary analgesic actions. Tablets of the drug, coated with an enteric coating, transiently pass the upper gastrointestinal tract without damaging the stomach, are absorbed in the small intestine by resorption of intact molecules (endocytosis, pinocytosis).

The proteases of the drug, binding with blood transport proteins (α-2-macroglobulin and α-1-antitrypsin), form a reversible protease-antiprotease complex in which the antigenic determinants of exogenous proteases of the drug are masked, which prevents allergic reactions. As a result of formation of the complex with enzymes, antiprotease (α-2-macroglobulin) changes into the active form which functions as an extracellular regulator of proinflammatory cytokines and growth factors, performing their transport, clearance and elimination.

The formation of an active protease-antiprotease complex allows proteolytic enzymes to move safely through the vascular bed to the focus of inflammation and to the site of injury, regardless of the localization in the body. The complex retains and slows down the elimination of proteolytic enzymes of the drug from the body, increases the time of their circulation in the vascular bed and accordingly the therapeutic effect. Getting into the center of inflammation and wounds, proteolytic enzymes break down (hydrolyze) damaged proteins, tissues and eliminate (remove) cellular debris (detritus), helping to accelerate wound cleansing and healing.

The drug has a positive effect on the course of the inflammatory process, modulates the body’s defense reactions, which contributes to the physiological course of inflammation at different stages. Proteolytic enzymes of the product accelerate decomposition of inflammatory mediators, break immune complexes and membrane deposits, increase activity of phagocytes and natural killer cells and stimulate interferonogenesis. Proteases of the drug decrease level of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, INF-γ, TNF-α) and increase production of anti-inflammatory cytokines (including IL-4, IL-10), regulate level of Ig and blood antibodies. Enzymes of the preparation limit pathological manifestations of autoimmune and immunocomplex processes and restore immunological reactivity of the body.

The proteases of the drug decrease the level of transforming growth factor β, the increase of which leads to excessive scarring. Proteolytic enzymes have a regulatory effect on the synchronization of basal membrane formation (laminin), modulation of the wound process and expression of angiogenesis factors (vasculoendothelial growth factor, fibroblast growth factor and several other factors). Thus the enzymes of the drug contribute to improvement of reparative processes, prevention of formation of hypertrophic and keloid scars, development of adhesions after surgical interventions on abdominal cavity.

The enzymes of the preparation decompose and remove damaged tissues, accelerate resolution of hematomas and edemas due to normalization of vascular wall permeability, decrease of interstitial infiltration by plasma proteins, increase of elimination of protein detritus and fibrin deposits, improvement of microcirculation and trophic processes in the damaged area. Optimization by proteolytic enzymes of the inflammatory process by reducing oncotic pressure and tissue edema, reducing pressure on nerve endings, elimination of ischemia and normalization of microcirculation, direct proteolysis of inflammatory mediators enables proteases to exert secondary analgesic effect. At the same time proteolytic enzymes provide stimulation of healing and reparation processes, decrease the risk of thromboembolic complications during long-term immobilization, prevent development of trophic disorders and purulent complications.

The enzymes of the drug have a positive effect on improvement of microcirculation, increasing delivery of oxygen and nutrients to the wound, reduction of inflammation in the lesion, maintaining the physiological process of regeneration and acceleration of organ and tissue function recovery.

The drug improves rheological properties of blood (viscosity and fluidity) due to positive effect on the functional state of blood cells and vascular wall, plasticity (deformability) of red blood cells, stabilization of endothelial permeability, increase of fibrinolytic activity of blood serum, decrease of density of adhesive molecules, decrease of platelet aggregation (sticking).

Proteolytic enzymes reduce the number of activated forms of platelets (spheroequinocytes) and micro- and macroaggregates, thus reducing the risk of thrombosis in blood vessels, and at the same time participate in the lysis of formed clots. Proteolytic enzymes reduce the level of atherogenic lipids, helping to increase HDL, reducing the risk of atherosclerosis and vascular disorders.

The preparation improves blood supply to bronchi and lung tissue of chronic respiratory diseases including those caused by smoking, improves viscosity of bronchial secretion, function of intermittent epithelium, restores drainage function of bronchi, thins sputum which facilitates breathing and reduces cough.

The product’s proteolytic enzymes increase the effectiveness of antibiotics while reducing the undesirable effects of antibiotic therapy (dysbiosis, irritable bowel syndrome). Proteases improve breakdown of substrates, optimize microbiota balance and contribute to restoration of intestinal endoecology.

Indications

In complex therapy and prevention of the following diseases and conditions:

Active ingredient

Composition

The active ingredients:

bromelain,

trypsin,

rutin (rutoside).

Excipients:

lactose,

Maize starch,

magnesium stearate,

stearic acid,

purified water,

anhydrous colloidal silica,

talc.

How to take, the dosage

In adults, 3 tablets 3 times a day for 2 weeks for treatment.

In prophylaxis, it is recommended that 2 tablets 3 times a day be used for 2 weeks.

Changing the dose of the drug or the course of treatment is determined by the doctor on an individual basis.

The tablets should be taken at least 30 min before a meal, without chewing, with water (200 ml).

Contraindications

With caution: performing hemodialysis (after consulting with a physician).

Side effects

Digestive system disorders: in some cases, increased frequency of stools, changes in the consistency and odor of stools. Nausea, flatulence, abdominal pain, feeling of fullness of the intestine.

Allergic reactions: rare – skin rash and itching.

CNS: headache, dizziness, exanthema, general weakness.

Pregnancy use

Use during pregnancy and lactation only after consultation with your doctor.