Flixonase, spray 50 mcg/dose 120 doses

GCS for intranasal use. It has a pronounced anti-inflammatory effect. When administered intranasally there is no systemic action, practically does not inhibit hypothalamic-pituitary-adrenal system.

No significant changes in the daily AUC of serum cortisol were found after administration of fluticasone propionate at a dose of 200 mcg/day compared to placebo (ratio: 1.01, 90% CI – confidence interval from 0.9 to 1.14).

The anti-inflammatory effect of fluticasone propionate is realized as a result of its interaction with glucocorticoid receptors. It suppresses proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils. Fluticasone propionate decreases production of inflammatory mediators and a number of biologically active substances (including histamine, prostaglandins, leukotrienes, cytokines) during the early and late phase of allergic reaction.

It has rapid anti-inflammatory effect on nasal mucosa. Anti-allergic effect appears 2-4 hours after the first use. It reduces sneezing, nasal itching, rhinorrhea, nasal congestion, nasal sinus discomfort and pressure sensation around nose and eyes.

It also reduces eye symptoms associated with allergic rhinitis. Reduction of symptoms (especially nasal congestion) persists for 24 hours after a single application of 200 mcg spray.

Fluticasone propionate improves patients’ quality of life, including physical and social activity.

Indications

Active ingredient

Composition

Active ingredient:

Fluticasone propionate (micronized) 50 mcg;

Ancillary substances:

anhydrous dextrose,

microcrystalline cellulose,

microcrystalline carboxymethylcellulose,

phenylethyl alcohol,

benzalkonium chloride solution,

polysorbate 80,

Hydrochloric acid diluted,

purified water.

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

Similarities