Flexid, 500 mg 14 pcs.

Levofloxacin is a broad-spectrum antimicrobial bactericidal drug, it blocks DNA-gyrease and topoisomerase IV, inhibits DNA synthesis.

It is active against aerobic gram-positive microorganisms:Enterococcus faecalis, Staphylococcus aureus (strains sensitive to methicillin), Staphylococcus haemolyticus (strains sensitive to methicillin), Staphylococcus saprophyticus, Streptococcus group C and G, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes; aerobic gram-negative microorganisms: Acinetobacter baumannii, Citrobacter freundii, Eikenella corrodens, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella oxytoca, Klebsiella pneumoniae, Moraxella catarrhalis, Morganella morganii, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Pseudomonas aeruginosa, Serratia marcescens; anaerobic microorganisms: Bacteroides fragilis, Clostridium perfringens, Peptostreptococcus spp.other microorganisms: Chlamydia pneumoniae, Chlamydia psittaci, Legionella pneumophila, Mycoplasma pneumoniae.

Aerobic gram-positive microorganisms are intermediately sensitive to the drug: Staphylococcus haemolyticus (methicillin-resistant strains); aerobic gram-negative microorganisms: Burkholderia cepacia; anaerobic microorganisms: Bacteroides ovatus, Bacteroides thetaiotamicron, Bacteroides vulgatus, Clostridium difficile.

Staphylococcus aureus (methicillin-resistant strains) are insensitive to levofloxacin.

Indications

Infections caused by strains of microorganisms sensitive to the drug:
– ENT organ infections (acute sinusitis);
– lower respiratory tract infections (acute bronchitis, chronic bronchitis, community-acquired pneumonia);
– Uncomplicated infections of the urinary tract and kidneys;
– Complicated infections of the urinary tract and kidneys (including pyelonephritis);
– Prostatitis;
– Skin and soft tissue infections.

Active ingredient

Composition

1 tablet contains:

The active ingredients:

levofloxacin (in hemihydrate form) 500 mg;

Associates:

Lactose monohydrate,

povidone,

How to take, the dosage

Flexid is taken orally: without regard to food intake, 250-500 mg once a day.

The duration of treatment depends on the indications for use.

In case of impaired renal function, adjustment of the mode of administration is required, including dose reduction according to creatinine clearance.

Contraindications

– epilepsy;
– tendon lesions that occurred during previous treatment with fluoroquinolones;
– age under 18 years;
– pregnancy;
–
– period of lactation (breastfeeding);
– hypersensitivity to levofloxacin or other quinolones, and/or to other components of Flexid.
Caution should be exercised:
– when prescribing levofloxacin in combination with drugs that affect tubular secretion, such as probenecid and cimetidine, especially when treating patients with impaired renal function;
– in treatment of patients with predisposition to epileptic seizures, during treatment with phenbufen and similar non-steroidal anti-inflammatory drugs (NSAIDs) or drugs that lower the threshold of epileptic seizures, such as theophylline;
– in patients with latent or obvious impairment of glucose-6-phosphate dehydrogenase activity due to the risk of hemolytic reactions.

Side effects

The following side effects were classified as follows: very common (>10%), common (1-10%), uncommon (0.1-1%), rare (0.01-0.1%), very rare (Digestive system disorders: common – nausea, diarrhea (incl.with blood admixture), increased activity of liver enzymes (ALT, AST); uncommon – decreased appetite, vomiting, abdominal pain, dyspepsia, hyperbilirubinemia; rare – enterocolitis, pseudomembranous colitis; very rare – hypoglycemia, hepatitis.

Nervous system disorders: uncommon – headache, dizziness, sleep disturbance; rare – paresthesias, tremor, anxiety, agitation, confusion, convulsions; very rare – hallucinations, extrapyramidal disorders and other coordination disorders.

Sensory organs: very rare – disorders of vision, hearing, smell, taste and tactile sensitivity.

Cardiovascular system disorders: rare – tachycardia, hypotension; very rare – vascular collapse.

Muscular system: rare – arthralgia, myalgia, tendinitis; very rare – tendon rupture (e.g., Achilles tendon), muscle weakness (of particular importance for myasthenic patients); in rare cases – rhabdomyolysis.

Urinary system disorders: uncommon – hypercreatininemia; very rare – interstitial nephritis, deterioration of renal function up to acute renal failure.

With the blood system and organs of blood formation: uncommon – eosinophilia, leukopenia; rare – neutropenia, thrombocytopenia; very rare – agranulocytosis; in single cases – hemolytic anemia, pancytopenia.

Allergic reactions: uncommon – itching, skin rash; rare – urticaria, bronchospasm, shortness of breath; very rare – angioedema, hypotension, anaphylactic shock, allergic pneumonitis, photosensitization; in single cases – Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), erythema multiforme.

Others: uncommon – asthenia; very rare – fever, vasculitis.

Similarities