Flexen, gel 2.5% 30 g

Flexen is an NSAID, a derivative of propionic acid.

It has analgesic, anti-inflammatory and antipyretic effects. Its mechanism of action is related to inhibition of activity of COX, major enzyme of arachidonic acid metabolism, which is precursor of prostaglandins playing main role in pathogenesis of inflammation, pain and fever.

The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly through inhibition of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in central and peripheral nervous system and also due to the effect on biological activity of other neurotropic substances which play key role in release of pain mediators in the spinal cord).

Ketoprofen also has anti-bradykinin activity, stabilizes lysosomal membranes and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.

Indications

Active ingredient

Composition

Active substance:

Ketoprofen 2.5 g.

How to take, the dosage

Flexen Gel: topically, apply a small amount of gel in a thin layer to the skin over the inflammation and gently rub in 2-3 times a day.

The duration of treatment should not exceed 14 days without medical advice.

Contraindications

Hypersensitivity (including to other NSAIDs), gastrointestinal diseases in the acute phase, marked renal and hepatic dysfunction, leukopenia, thrombocytopenia, blood clotting disorders, hemorrhoids and proctitis (suppositories), pregnancy, lactation, children under 15 years.

Side effects

Nervous system and sense organs: dizziness, headache, asthenia.

Gastrointestinal organs: gastralgia, nausea, vomiting, diarrhea, flatulence, gastrointestinal hemorrhages.

Others: transient dysuria, skin allergic reactions (itching, urticaria).

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