Fexofast, 180 mg 10 pcs

Fexofast has an antihistamine, anti-allergic effect. Fexofenadine hydrochloride is a non-sedative blocker of H1 – histamine receptors, it is pharmacologically active metabolite of terfenadine.

The antihistamine effect appears 1 hour after intake, reaches a maximum after 6 hours and lasts for 24 hours. No development of tolerance has been noted with repeated use.

It does not have choline and adrenolytic, sedative action. Does not cause changes of calcium and potassium channel function and QT interval in therapeutic doses.

Pharmacokinetics

After oral administration it is quickly absorbed from the gastrointestinal tract, time after reaching maximum concentration (TC_max) is 1-3 hours.

The mean maximum concentration (C_mah) after 180 mg administration is approximately 494 ng/mL, after 120mg administration is 427 ng/mL. The binding to plasma proteins is 60-70% (predominantly to albumin and alpha1-glycoprotein).

It does not pass through blood-brain barrier. elimination half-life (T1/2) after multiple administration – 14.4 hours.

In patients with moderate (creatinine clearance 41-80 ml/min) and severe (11-40 ml/min) renal impairment the T1/2 is increased by 59 and 72% respectively; in patients on hemodialysis the T1/2 is increased by 31%.

It is subjected (5% of the dose) to partial extrahepatic metabolism. It is eliminated mainly (80%) with bile, 11% – by kidneys unchanged.

Indications

Seasonal allergic rhinitis, chronic idiopathic urticaria.

Active ingredient

Composition

1 film-coated tablet contains:

the active substance:

fexofenadine 180 mg;

excipients:

Microcrystalline cellulose,

starch,

lactose,

croscarmellose sodium (primellose),

How to take, the dosage

Fexofast is taken orally. Adults and children over 12 years of age in chronic idiopathic urticaria – 180 mg once daily.

Interaction

When co-administration with erythromycin or ketoconazole plasma concentrations of fexofenadine are increased by 2-3 times.

Taking aluminum- or magnesium-containing antacids 15 min before taking fexofenadine decreases bioavailability of the latter (the time interval between their intake should be at least 2 hours).

It does not interact with omeprazole, with drugs metabolized in the liver.

Special Instructions

When taking the drug Fexofast it is possible to perform work requiring high concentration and quick psychomotor reactions (except for people who have non-standard reactions to medicines).

Hence, before starting to perform these works (driving, operating machinery) it is necessary to check the individual reaction to the drug first.

Contraindications

With caution: Chronic renal insufficiency. (Recommended daily dose in such patients is 60 mg once).

Side effects

Rarely (less than 1 case per 1000 prescriptions):

In individual cases:

Overdose

Symptoms: dizziness, drowsiness and dry mouth.

In case of overdose, standard measures for removal of the unabsorbed drug from the gastrointestinal tract are recommended.

Symptomatic and supportive therapy is recommended.

Hemodialysis is ineffective.

Similarities