Fencarol, tablets 10 mg 20 pcs

Phencarol – antiexudative, antipruritic, anti-allergic, anti-edematous.

Pharmacodynamics

The active substance of the drug is chyphenadine, a blocker of H1-histamine receptors, which prevents the development and facilitates the allergic reactions. It has anti-allergic, antiexudative and antipruritic action, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing the permeability, it has an anti-edema effect), reduces its bronchospastic action and spasmogenic effect on the smooth muscles of the intestine, weakens the hypotensive effect of histamine. Hiphenadine reduces the content of histamine in the tissues (due to the ability to activate diamine oxidase – an enzyme that inactivates histamine). When treating with a course of treatment, the antihistamine effect of quiphenadine is not reduced. It has moderate antiserotonin action, shows weak m-cholin-blocking activity. It does not have depressing effect on the CNS.

Pharmacokinetics

45% of quiphenadine is quickly absorbed from the gastrointestinal tract and is already found in the body tissues after 30 minutes. Cmax of active substance in blood plasma is reached after 1 hour. It has low lipophilicity, poor penetration through the BBB. The highest content of the active substance is observed in liver, a little less in lungs and kidneys, the lowest – in brain (less than 0.05%, which explains the absence of suppressive effect on CNS). Hyphenadine is metabolized in the liver. Metabolites are excreted by the kidneys and intestines. The unabsorbed part of the drug is excreted from the intestine.

Indications

Hay fever, acute and chronic urticaria, angioedema, allergic rhinitis, dermatoses, including eczema, atopic dermatitis, itching.

Pharmacological effect

Khifenadine is a blocker of H1-histamine receptors, prevents the development and alleviates the course of allergic reactions. It has antiallergic, antiexudative and antipruritic effects, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing permeability, it has an anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine. Hifenadine reduces the content of histamine in tissues (associated with the ability to activate diamine oxidase, an enzyme that inactivates histamine). During a course of treatment, the antihistamine effect of quifenadine does not decrease. It has a moderate antiserotonin effect and exhibits weak M-anticholinergic activity. Does not have a depressing effect on the central nervous system.

Active ingredient

Hifenadine

Composition

active ingredient: hifenadine hydrochloride 10 mg;
excipients: potato starch 14.5 mg, sucrose 25.0 mg, calcium stearate 0.5 mg.

Contraindications

– Hypersensitivity to any of the components of the drug.
– Pregnancy, lactation period.
– Sucrase/isomaltase deficiency, fructose intolerance, glucose/galactose malabsorption, since the drug contains sucrose.
– Children under 18 years of age (for a dosage of 50 mg)
– Children under 3 years of age (for tablets 10, 25 mg)

Side Effects

Dryness of the oral mucosa, nausea, vomiting, drowsiness, allergic reactions, headache.

Interaction

Hifenadine does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system. Having weak M-anticholinergic properties, it can reduce gastrointestinal motility and increase the absorption of slowly absorbed drugs (for example, indirect anticoagulants – coumarin derivatives).

Overdose

Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspeptic symptoms. Treatment is symptomatic. It is necessary to rinse the stomach, take activated charcoal, and consult a doctor immediately.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life

4 years

Manufacturer

Olainfarm, Latvia