Fencarol, tablets 10 mg 20 pcs

Phencarol – antiexudative, antipruritic, anti-allergic, anti-edematous.

Pharmacodynamics

The active substance of the drug is chyphenadine, a blocker of H1-histamine receptors, which prevents the development and facilitates the allergic reactions. It has anti-allergic, antiexudative and antipruritic action, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing the permeability, it has an anti-edema effect), reduces its bronchospastic action and spasmogenic effect on the smooth muscles of the intestine, weakens the hypotensive effect of histamine. Hiphenadine reduces the content of histamine in the tissues (due to the ability to activate diamine oxidase – an enzyme that inactivates histamine). When treating with a course of treatment, the antihistamine effect of quiphenadine is not reduced. It has moderate antiserotonin action, shows weak m-cholin-blocking activity. It does not have depressing effect on the CNS.

Pharmacokinetics

45% of quiphenadine is quickly absorbed from the gastrointestinal tract and is already found in the body tissues after 30 minutes. Cmax of active substance in blood plasma is reached after 1 hour. It has low lipophilicity, poor penetration through the BBB. The highest content of the active substance is observed in liver, a little less in lungs and kidneys, the lowest – in brain (less than 0.05%, which explains the absence of suppressive effect on CNS). Hyphenadine is metabolized in the liver. Metabolites are excreted by the kidneys and intestines. The unabsorbed part of the drug is excreted from the intestine.

Indications

Active ingredient

Composition

Active ingredient:

quiphenadine hydrochloride 10 mg.

Excipients:

sugar,

potato starch,

calcium stearate.

How to take, the dosage

The drug should be taken orally, after meals. The course of treatment for adults is 10-20 days, repeated if necessary. The course of treatment for children is 10-15 days.

The recommended dosage: adults – 25-50 mg 3-4 times a day (maximum daily dose – 200 mg); children from 2 to 3 years – 5 mg 2-3 times a day; children 3-7 years – 10 mg 2 times a day; children 7-12 years – 10-15 mg 2-3 times a day.

Interaction

Does not increase the depressant effect of alcohol and sleeping pills on the central nervous system.

With weak M-cholin-blocking properties, may decrease gastrointestinal motility and increase absorption of slowly absorbed drugs (e.g., indirect-acting anticoagulants – coumarins).

Special Instructions

The absence of a pronounced cholin-blocking effect allows the use in patients for whom antihistamines with anticholinergic activity are contraindicated.

Impact on the ability to drive and operate machinery:

Persons whose profession requires rapid mental and motor reactions should determine in advance (by short-term administration) whether the drug has a sedative effect.

Contraindications

– Individual intolerance to the drug.

– Pregnancy, lactation.

– Childhood under 3 years of age (for this dosage form).

– Sugars/isomaltase deficiency fructose intolerance glucose/galactose malabsorption because the drug contains sucrose.

Side effects

Digestive system disorders: dry mouth, nausea, vomiting.

CNS disorders: drowsiness, headache.

Others: allergic reactions.

Overdose

Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspeptic phenomena.

Treatment: symptomatic. It is necessary to flush the stomach, take activated charcoal, see a doctor immediately.

Pregnancy use

It is not recommended for use throughout pregnancy. If it is necessary to use during pregnancy, the balance between the expected benefits to the mother and the risk to the fetus should be carefully weighed. Breast-feeding should be discontinued if treatment with the drug is necessary

The mild m-cholinoblocking effect allows administration of quiphenadine in patients who are contraindicated for antihistamines with m-cholinoblocking activity.