Etoxysclerol, 30 mg/ml 2 ml 5 pcs

Etoxysclerol has a venosclerosing, local anesthetic effect. It damages the vascular endothelium, causing denaturation of proteins, stimulates rapid thrombus formation and its organization within 7 days.

Ethoxysclerol reduces the excitability of nerve endings and the conduction of the pain impulse, ensuring painless sclerotherapy.

Pharmacokinetics

The volume of distribution is 24.5 L, binding to plasma proteins is 64%, T1/2 is 4 hours. Total Cl – 11.7 l/h, renal – 2.43 l/h, biliary – 3.14 l/h. It does not cumulate with repeated injections.

Indications

Symptomatic treatment of functional asthenia.

Pharmacological effect

Ethoxysclerol has a venosclerosing, local anesthetic effect. Damages the vascular endothelium, causing denaturation of proteins, stimulates the rapid formation of a blood clot and its organization within 7 days.

Ethoxysklerol reduces the excitability of nerve endings and the conductivity of pain impulses, ensuring painlessness of sclerotherapy.

Pharmacokinetics

Volume of distribution – 24.5 l, plasma protein binding – 64%, T1/2 – 4 hours. Total Cl – 11.7 l/h, renal – 2.43 l/h, biliary – 3.14 l/h. Does not accumulate with repeated administrations.

Special instructions

CHF in the compensation phase and stable arterial hypertension are not contraindications for sclerotherapy.

Sclerosing drugs cannot be administered intravenously, because this can lead to severe necrosis and forced amputation. In case of accidental intravenous administration, inject 5-10 ml of a 1-2% solution of lidocaine or mepivacaine, 500 IU of heparin into the needle left in the artery; wrap the limb in cotton wool and lower it down; hospitalize the patient in the vascular surgery department.

The introduction of sclerosing drugs into the veins of the facial part of the skull is carried out only according to strict indications.

Active ingredient

Lauromacrogol-400

Composition

Active substance:

polidocanol 5 mg.

Pregnancy

Contraindicated in the first trimester of pregnancy and after 36 weeks;

It is recommended to stop breastfeeding after administration of Ethoxysklerol for 2-3 days.

Contraindications

Hypersensitivity to the drug Ethoxysclerol, bronchial asthma, diabetes mellitus

Side Effects

When sclerosing varicose veins of the extremities: hyperpigmentation of the skin at the injection site of Ethoxysclerol.

When sclerosing hemorrhoids: transient pain.

When sclerosing varicose veins of the esophagus and stomach: necrosis, ulceration and stenosis of the esophagus, exudation into the pleural cavity, dysphagia, fever, anaphylactic shock.

Interaction

Enhances the arrhythmogenic activity of local anesthetics and drugs for general anesthesia.

Overdose

Symptoms: with paravasal administration – necrosis.

Treatment: administration of 0.5-2 ml of 1% procaine solution or 5-20 ml of 0.9% NaCl solution in combination with hyaluronidase.

Storage conditions

In a dry place, at a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Siegfried Hameln GmbH, Germany