Esslial forte, 300 mg capsules 30 pcs

Essential phospholipids are the basic elements of the structure of the liver cell envelope and cell organelles. In case of liver diseases there is always damage of liver cell membranes and their organelles, which leads to disturbances in activity of associated enzymes and receptor systems, deterioration of functional activity of liver cells and decreased ability to regenerate.

Phospholipids contained in the preparation

Esslial forte correspond in their chemical structure to endogenous phospholipids, but exceed the activity of endogenous phospholipids due to their higher content of polyunsaturated (essential) fatty acids.

Incorporation of these high-energy molecules into damaged sections of hepatocyte cell membranes restores integrity of hepatic cells and promotes regeneration.

Cis-double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in phospholipids of cell membranes, the density of phospholipid structure of cell membranes of hepatocytes decreases, thus increasing their fluidity and elasticity and improving metabolism.

The formed functional blocks increase the activity of membrane-fixed enzymes and contribute to the normal physiological way of essential metabolic processes.

Phospholipids contained in the drug

Esslial forte regulates the metabolism of lipoproteins, transferring neutral fats and cholesterol to the sites of oxidation, mainly by increasing the ability of high density lipoproteins to bind to cholesterol.

Thus there is a normalizing effect on lipid and protein metabolism, the detoxifying function of the liver and phospholipid-dependent enzyme systems, which ultimately prevents the formation of connective tissue in the liver and promotes natural regeneration of liver cells.

Phospholipids excretion into the bile decreases the lithogenic index and stabilizes the bile

Indications

Chronic hepatitis,
cirrhosis,
fatty liver of various etiologies,
toxic liver damage,
alcoholic hepatitis,
liver dysfunction in other somatic diseases.
Toxicosis of pregnancy,
prevention of recurrence of gallstone formation,
psoriasis (as an adjuvant therapy),
radiation syndrome.

Pharmacological effect

Essential phospholipids are the main elements of the structure of the cell membrane and cellular organelles of the liver. In liver diseases, there is always damage to the membranes of liver cells and their organelles, which leads to disturbances in the activity of associated enzymes and receptor systems, deterioration in the functional activity of liver cells and a decrease in the ability to regenerate.

Phospholipids included in the preparation

Esslial forte correspond in their chemical structure to endogenous phospholipids, but are superior to endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids.

The integration of these high-energy molecules into damaged areas of hepatocyte cell membranes restores the integrity of liver cells and promotes their regeneration.

The cis-double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in the phospholipids of cell membranes; the density of the phospholipid structure of the cell membranes of hepatocytes decreases, which causes an increase in their fluidity and elasticity, and improves metabolism.

The resulting functional blocks increase the activity of enzymes fixed on membranes and contribute to the normal physiological pathway of the most important metabolic processes.

Phospholipids included in the preparation

Esslial forte regulates the metabolism of lipoproteins, transferring neutral fats and cholesterol to sites of oxidation, mainly by increasing the ability of high-density lipoproteins to bind to cholesterol.

Thus, there is a normalizing effect on the metabolism of lipids and proteins; on the detoxification function of the liver and phospholipid-dependent enzyme systems; which ultimately prevents the formation of connective tissue in the liver and promotes the natural restoration of liver cells.

When phospholipids are excreted into bile, the lithogenic index decreases and bile stabilizes

Active ingredient

Phospholipids

Composition

1 capsule contains:

Active substance:

lipoid PPL-400 – 400.0 mg, in terms of polyunsaturated phospholipids from soy lecithin (PPL fraction) – 300.0 mg, with an average content of L-α-phosphatidylcholine 76% – 228.0 mg.

Excipients:

ethyl alcohol 95% – 4.0 mg.

Hard gelatin capsules No. 0:

Composition of the capsule body: black iron oxide dye – 0.01%, red iron oxide dye – 0.01%, yellow iron oxide dye – 0.1714%, titanium dioxide – 3%, gelatin – up to 100%;

Composition of the capsule cap: black iron oxide dye – 0.53%, red iron oxide dye – 0.93%, yellow iron oxide dye – 0.2%, titanium dioxide – 0.3333%, gelatin – up to 100%

Contraindications

Individual intolerance to phosphatidylcholine or other auxiliary components of the drug.

Soy intolerance.

Children under 12 years of age (lack of sufficient evidence base).

Side Effects

Esslial forte is usually well tolerated by patients.

For the purpose of assessing the frequency of side effects, the following definitions are used:

very often (>1/10), often (>1/100 – <1/10),not often (>1/1000 – <1/100),rare (>1/10000 – <1/1000),very rare (< 1/10000),unknown frequency (from the available data it is impossible to determine the frequency of occurrence).From the gastrointestinal tract:rarely – discomfort in the epigastric region, loose stools, nausea, gastralgia.Allergic reactions: very rarely – rash, exanthema, urticaria; unknown frequency – itching.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ºС.
Keep out of the reach of children.

Shelf life

3 years. Do not use after the expiration date stated on the package.

Manufacturer

Ozon, Russia