Erythromycin, ointment 10000 units/g tube 15 g

Erythromycin is a bacteriostatic antibiotic from the macrolide group.

In external use it has antibacterial and anti-acne action.

Binds irreversibly to 50S subunit of ribosomes which disrupts formation of peptide bonds between amino acid molecules and blocks protein synthesis in microorganisms (does not affect nucleic acid synthesis).

When used in high doses depending on the type of pathogen it may show bactericidal effect.

The spectrum of action includes gram-positive (Staphylococcus spp., Streptococcus spp, Bacillus anthracis, Corynebacterium diphtheriae) and gram-negative (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp.) microorganisms, as well as Mycoplasma spp., Chlamidia spp., Treponema spp., Rickettsia spp. Gram-negative bacilli Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Bacteroides fragilis, Enterobacter spp. are resistant to the drug. Etc.

Indications

Infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, bedsores, stage II-III burns, trophic ulcers).

Pharmacological effect

Erythromycin is a bacteriostatic antibiotic from the macrolide group.

When used externally, it has an antibacterial and anti-acne effect.

Reversibly binds to the 50S subunit of ribosomes, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of microbial proteins (does not affect the synthesis of nucleic acids).

When used in high doses, depending on the type of pathogen, it can exhibit a bactericidal effect.

The spectrum of action includes gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium diphtheriae) and gram-negative (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp.) microorganisms, as well as Mycoplasma spp., Chlamydia spp., Treponema spp., Rickettsia spp. Gram-negative bacilli Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Bacteroides fragilis, Enterobacter spp. are resistant to the drug. Etc.

Special instructions

Wait at least 1 hour before using any other anti-acne medication for external use.

If your acne does not improve within 3-4 weeks, you should consult your doctor (it may take 2-3 months to achieve the full therapeutic effect.

With prolonged use, superinfection may develop.

Active ingredient

Erythromycin

Composition

1 g ointment contains:

active ingredient:

erythromycin – 10 thousand units;

excipients:

anhydrous lanolin – 0.4 g,

sodium disulfite (sodium metabisulfite, sodium pyrosulfite) – 0.0001 g,

Vaseline up to 1 g.

Contraindications

Individual hypersensitivity.

Side Effects

The development of allergic reactions and irritating effects (redness, itching) is possible. With prolonged use, a secondary infection caused by erythromycin-resistant microorganisms may develop.

Interaction

The drug is incompatible with lincomycin, clindamycin, chloramphenicol (antagonism).

Reduces the bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems).

When simultaneous use of erythromycin dosage forms for external use with abrasive substances that lead to excessive skin irritation, as well as with drugs that cause peeling of the skin, a cumulative irritating or drying effect is possible.

Storage conditions

At a temperature not exceeding 25 C. Store out of the reach of children.

Shelf life

5 years.

Manufacturer

Sintez, Russia