Erythromycin, ointment 10000 units/g tube 15 g

Erythromycin is a bacteriostatic antibiotic from the macrolide group.

In external use it has antibacterial and anti-acne action.

Binds irreversibly to 50S subunit of ribosomes which disrupts formation of peptide bonds between amino acid molecules and blocks protein synthesis in microorganisms (does not affect nucleic acid synthesis).

When used in high doses depending on the type of pathogen it may show bactericidal effect.

The spectrum of action includes gram-positive (Staphylococcus spp., Streptococcus spp, Bacillus anthracis, Corynebacterium diphtheriae) and gram-negative (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp.) microorganisms, as well as Mycoplasma spp., Chlamidia spp., Treponema spp., Rickettsia spp. Gram-negative bacilli Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Bacteroides fragilis, Enterobacter spp. are resistant to the drug. Etc.

Indications

Infections of skin and soft tissue (pustular skin diseases, including juvenile acne, infected wounds, bedsores, II-III degree burns, trophic ulcers).

Active ingredient

Composition

1 g of the ointment contains:

the active ingredient:

erythromycin – 10 thousand.IU;

auxiliary substances:

lanolin anhydrous – 0.4 g,

Sodium disulfite (sodium metabisulfite, sodium pyrosulfite) – 0.0001 g,

Vaseline up to 1 g.

How to take, the dosage

Outwardly: apply the ointment to the affected skin 2-3 times a day, treatment duration – 1.5-2 months.

In case of purulent skin and soft tissue diseases the ointment is applied to the affected area of the skin in a thin layer 1-2 times a day after removal of necrotic masses and pus; if burns – 2-3 times a week.

The duration of treatment depends on the form and severity of the disease and varies from several days to two weeks.

Interaction

The drug is incompatible with lincomycin, clindamycin, chloramphenicol (antagonism).

The bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems) is reduced.

The simultaneous use of topical dosage forms of erythromycin with abrasive agents that lead to excessive skin irritation, as well as with drugs that cause skin flaking, may result in a cumulative irritating or drying effect.

Special Instructions

A minimum of 1 hour should pass before using any other topical acne medication.

If acne does not improve within 3-4 weeks, a physician should be consulted (it may take 2-3 months to achieve full therapeutic effect.

Long-term use may lead to superinfection.

Contraindications

Individual hypersensitivity.

Side effects

Allergic reactions and irritation (redness, itching) may develop. With prolonged use, secondary infection caused by erythromycin-resistant microorganisms may develop.

Similarities