Erythromycin, eye ointment 10000 units/g tube 10 g

A bacteriostatic antibiotic of the macrolide group. When used externally it has antibacterial and anti-acne effect. It binds irreversibly to 50S subunit of ribosomes, which disrupts formation of peptide bonds between amino acid molecules and blocks protein synthesis in microorganisms (it does not affect nucleic acid synthesis). When used in high doses depending on the type of pathogen it may show bactericidal effect.

The spectrum of action includes gram-positive (Staphylococcus spp., Streptococcus spp, Bacillus anthracis, Corynebacterium diphtheriae) and gram-negative (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp.) microorganisms, as well as Mycoplasma spp., Chlamidia spp., Treponema spp., Rickettsia spp.

The drug is resistant to Gram-negative bacilli Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Bacteroides fragilis, Enterobacter spp. Etc.

Indications

Infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, bedsores, II-III degree burns, trophic ulcers).

Active ingredient

Composition

1 g of ointment contains:

Active substance:

erythromycin (in terms of the active substance) – 10 thousandIU;

Auxiliary substances:

Lanolin anhydrous – 0.4 g,

Sodium disulfite (sodium metabisulfite, sodium pyrosulfite) – 0.0001 g,

Vaseline up to 1 g.

How to take, the dosage

Outwardly: apply the ointment to the affected skin 2-3 times a day, treatment duration – 1.5-2 months. For purulent skin and soft tissue diseases the ointment is applied to the affected area of the skin in a thin layer 1-2 times a day after removal of necrotic masses and pus, for burns – 2-3 times a week. Duration of treatment depends on the form and severity of the disease and ranges from a few days to 2 weeks.

Interaction

The drug is incompatible with lincomycin, clindamycin, chloramphenicol (antagonism).

The bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems) is reduced.

In concurrent use of topical dosage forms of erythromycin with abrasive substances that lead to excessive skin irritation, as well as with drugs that cause skin flaking, a cumulative irritating or drying effect is possible.

Special Instructions

A minimum of 1 hour should pass before using any other topical acne medication.

If acne does not improve within 3-4 weeks, a physician should be consulted (it may take 2-3 months to achieve full therapeutic effect.

Long-term use may lead to superinfection.

Contraindications

Individual hypersensitivity.

Side effects

Allergic reactions and irritation (redness, itching) may develop.

Long-term use may lead to secondary infection caused by erythromycin-resistant microorganisms.

Overdose

There are no data on overdose of the drug.

Similarities