Eleflox, 500 mg 10 pcs

A broad spectrum antimicrobial agent. It has a pronounced bactericidal effect The drug inhibits both subunits of DNA-gyrase and topoisomerase IV, destroys the bacterial cell wall. It is also active against pneumococci and intracellular pathogens.

Owing to extremely high bioavailability and easy penetration inside the cell Eleflox reaches high concentrations in interstitial tissue fluid and inside cells.

The drug is usually administered once daily. 87% of Eleflox is excreted with urine in the active form, due to which high concentrations are achieved in the urogenital organs and prostate.

There is no need to adjust the dose if liver function is impaired. No change in dosing regimen is required for elderly patients, except in cases of low creatinine clearance.

Indications

Infectious and inflammatory diseases caused by susceptible microorganisms:

Active ingredient

Composition

Levofloxacin 500 mg.

How to take, the dosage

Interaction

Levofloxacin increases T1/2 of cyclosporine.

The effect of levofloxacin is reduced by drugs that inhibit intestinal motility, sucralfate, magnesium- and aluminum-containing antacids and iron salts (a break of at least 2 hours between doses is necessary).

Concomitant use of NSAIDs, theophylline increases seizure activity, and GCS increases the risk of tendon rupture.

Cimetidine and drugs that block tubular secretion slow the excretion of levofloxacin.

Special Instructions

Cautious use of levofloxacin in elderly patients (high probability of concomitant decreased renal function).

After normalization of fever it is recommended to continue treatment for at least 48-78 hours. The duration of the intravenous infusion of 500 mg (100 ml infusion solution) should be at least 60 minutes. During treatment, sunlight and artificial UV exposure should be avoided to avoid skin damage (photosensitization). If signs of tendinitis appear, levofloxacin should be immediately discontinued. It should be borne in mind that patients with a history of brain damage (stroke, severe trauma) may develop convulsions, with insufficiency of glucose-6-phosphate dehydrogenase – risk of hemolysis.

Impact on driving and operating machinery

At the time of treatment it is necessary to refrain from potentially dangerous activities requiring increased concentration and rapid psychomotor reactions.

Contraindications

Hypersensitivity, epilepsy, tendon lesions from previous treatment with quinolones, pregnancy, lactation, children and adolescents under 18 years of age.

Side effects

Digestive system disorders: nausea, vomiting, diarrhea, anorexia, abdominal pain, pseudomembranous enterocolitis, increased liver transaminases activity, hyperbilirubinemia, hepatitis, dysbacteriosis.

Cardiovascular system disorders: decreased BP, vascular collapse, tachycardia.

Metabolic disorders: hypoglycemia (increased appetite, sweating, shivering).

CNS and peripheral nervous system disorders: headache, dizziness, weakness, drowsiness, insomnia, paresthesias, anxiety, fear, hallucinations, confusion, depression, motor disorders, seizures.

Sensory organs: disorders of vision, hearing, smell, taste and tactile sensitivity.

Muscular system disorders: arthralgia, myalgia, tendon rupture, muscle weakness, tendinitis.

Urinary system disorders: hypercreatininemia, interstitial nephritis.

Hematopoietic system disorders: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhages.

Dermatological reactions: photosensitization, itching, swelling of the skin and mucous membranes, erythema malignant exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

Allergic reactions: urticaria, bronchospasm, choking, anaphylactic shock, allergic pneumonitis, vasculitis.

Others: exacerbation of porphyria, rhabdomyolysis, persistent fever, development of superinfection.

Pregnancy use

Levofloxacin is contraindicated in pregnancy and during lactation (breastfeeding).

Similarities